ArticleNeuropharmacology2010
Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample.
Article in Neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Influence of rhythmic-movement activity intervention on hot executive function of 5- to 6-year-old children.Frontiers in psychology · 2024Article
- Genetic predictors of cultural values variation between societies.Scientific reports · 2023Article
- Early musical training benefits to non-musical cognitive ability associated with the Gestalt principles.Frontiers in psychology · 2023Article
- Can cognition help predict suicide risk in patients with major depressive disorder? A machine learning study.BMC psychiatry · 2022Article
- Problematic social media use is associated with the evaluation of both risk and ambiguity during decision making.Journal of behavioral addictions · 2021Article
- Social-networks-related stimuli interferes decision making under ambiguity: Interactions with cue-induced craving and problematic social-networks use.Journal of behavioral addictions · 2021Article
- The Negative Association Between Positive Psychological Wellbeing and Loss Aversion.Frontiers in psychology · 2021Article
- A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction.Psychological science in the public interest : a journal of the American Psychological Society · 2019Review
- Excessive social media users demonstrate impaired decision making in the Iowa Gambling Task.Journal of behavioral addictions · 2019Article
- The neuroanatomical basis of the Gambler's fallacy: A univariate and multivariate morphometric study.Human brain mapping · 2019Article
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- 5-HTTLPR moderates the association between interdependence and brain responses to mortality threats.Human brain mapping · 2017Article
- Heightened aversion to risk and loss in depressed patients with a suicide attempt history.Scientific reports · 2017Article
- Toward a multiscale modeling framework for understanding serotonergic function.Journal of psychopharmacology (Oxford, England) · 2017Review
- Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.Social cognitive and affective neuroscience · 2017Article
- Genetic variation of dopamine and serotonin function modulates the feedback-related negativity during altruistic punishment.Scientific reports · 2017Article
- Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Risky decision making is a complex process that involves weighing the probabilities of alternative options that can be desirable, undesirable, or neutral. Individuals vary greatly in how they make decisions either under ambiguity and/or under risk. Such individual differences may have genetic bases. Based on previous studies on the genetic basis of decision making, two decision making tasks [i.e., the Iowa Gambling Task (IGT) and Loss Aversion Task (LAT)] were used to test the effect of 5-HTTLPR polymorphism on decision making under ambiguity and under risk in a large Han Chinese sample (572 college students, 312 females). Basic intelligence and memory tests were also included to control for the influence of basic cognitive abilities on decision making. We found that 5-HTTLPR polymorphism significantly influenced performance in both IGT and LAT. After controlling for intelligence and memory abilities, subjects homozygous for s allele had lower IGT scores than l carriers in the first 40 trials of the IGT task. They also exhibited higher loss aversion than l carriers in the LAT task. Moreover, the effects of 5-HTTLPR were stronger for males than for females. These results extend the literature on the important role of emotion in decision making under ambiguity and risk, and shed additional lights on how decision making is influenced by culture as well as sex differences. Combining our results with existing literature, we propose that these effects might be mediated by a neural circuitry that comprises the amygdala, ventromedial prefrontal cortex, and insular cortex. Understanding the genetic factors affecting decision making in healthy subjects may allow us to better identify at-risk individuals, and better target the development of new potential treatments for specific disorders such as schizophrenia, addiction, and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.