ArticleEnvironmental health : a global access science source2010
HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.
Article in Environmental health : a global access science source, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Prenatal chemical exposures and fetal growth: a narrative review of gene-environment interactions (2025).Pediatric research · 2026Review
- Article
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study.Frontiers in genetics · 2021Article
- Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low-level lead exposure in children.Environmental research · 2018Article
- A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure.PLoS genetics · 2017Article
- Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility.Environment international · 2017Article
- The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster.Environmental health perspectives · 2016Article
- Variation in an Iron Metabolism Gene Moderates the Association Between Blood Lead Levels and Attention-Deficit/Hyperactivity Disorder in Children.Psychological science · 2016Article
- Latent variable models for gene-environment interactions in longitudinal studies with multiple correlated exposures.Statistics in medicine · 2015Article
- Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study.Environmental health : a global access science source · 2014Article
- Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.Neurotoxicology · 2013Article
- A latent variable approach to study gene-environment interactions in the presence of multiple correlated exposures.Biometrics · 2012Article
- A dopamine receptor (DRD2) but not dopamine transporter (DAT1) gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure.The Journal of pediatrics · 2011Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundNeonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight.
methodsWe investigated the role of HFE C282Y, HFE H63 D, and transferrin (TF) P570 S gene variants in modifying the association of lead and infant birthweight in a cohort of Mexican mother-infant pairs. Subjects were initially recruited between 1994-1995 from three maternity hospitals in Mexico City and 411 infants/565 mothers had archived blood available for genotyping. Multiple linear regression models, stratified by either maternal/infant HFE or TF genotype and then combined with interaction terms, were constructed examining the association of lead and birthweight after controlling for covariates.
results3.1%, 16.8% and 17.5% of infants (N=390) and 1.9%, 14.5% and 18.9% of mothers (N=533) carried the HFE C282Y, HFE H63D, and TF P570 S variants, respectively. The presence of infant HFE H63 D variants predicted 110.3 g (95% CI -216.1, -4.6) decreases in birthweight while maternal HFE H63 D variants predicted reductions of 52.0 g (95% CI -147.3 to 43.2). Interaction models suggest that both maternal and infant HFE H63 D genotype may modify tibia lead's effect on infant birthweight in opposing ways. In our interaction models, maternal HFE H63 D variant carriers had a negative association between tibia lead and birthweight.
conclusionsThese results suggest that the HFE H63 D genotype modifies lead's effects on infant birthweight in a complex fashion that may reflect maternal-fetal interactions with respect to the metabolism and transport of metals.
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