ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2010
Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Intrinsic tumor cell line immunogenicity may drive CAR-independent T cell responses and confound CAR T cell preclinical modeling.Journal for immunotherapy of cancer · 2026Article
- Review
- Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality.The Journal of clinical investigation · 2023Article
- Review
- CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation.Frontiers in immunology · 2021Article
- Impact of infection on transplantation tolerance.Immunological reviews · 2019Review
- Natural killer cells in lung transplantation.Thorax · 2019Review
- Impact of environmental factors on alloimmunity and transplant fate.The Journal of clinical investigation · 2017Review
- Transplantation tolerance after allograft rejection.Current opinion in organ transplantation · 2017Review
- Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.Frontiers in immunology · 2016Review
- Prenatal Allogeneic Tolerance in Mice Remains Stable Despite Potent Viral Immune Activation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Microbiota—implications for immunity and transplantation.Nature reviews. Nephrology · 2015Review
- Transplantation tolerance and its outcome during infections and inflammation.Immunological reviews · 2014Review
- Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Microbes and allogeneic transplantation.Transplantation · 2014Review
- Cross-reactive anti-viral T cells increase prior to an episode of viral reactivation post human lung transplantation.PloS one · 2013Article
- T-cell activation and transplantation tolerance.Transplantation reviews (Orlando, Fla.) · 2012Review
- The impact of infection and tissue damage in solid-organ transplantation.Nature reviews. Immunology · 2012Review
- TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition.Immunogenetics · 2012Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Viral infections have been associated with the rejection of transplanted allografts in humans and mice, and the induction of tolerance to allogeneic tissues in mice is abrogated by an ongoing viral infection and inhibited in virus-immune mice. One proposed mechanism for this 'heterologous immunity' is the induction of alloreactive T cell responses that cross-react with virus-derived antigens. These cross-reactive CD8 T cells are generated during acute viral infection and survive into memory, but their ability to partake in the immune response to allografts in vivo is not known. We show here that cross-reactive, virus-specific memory CD8 T cells from mice infected with LCMV proliferated in response to allografts. CD8 T cells specific to several LCMV epitopes proliferated in response to alloantigens, with the magnitude and hierarchy of epitope-specific responses varying with the private specificities of the host memory T cell repertoire, as shown by adoptive transfer studies. Last, we show that purified LCMV-specific CD8 T cells rejected skin allografts in SCID mice. These findings therefore implicate a potential role for heterologous immunity in virus-induced allograft rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.