ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Three pleiotropic loci associated with bone mineral density and lean body mass.Molecular genetics and genomics : MGG · 2021Pooled it
- Osteosarcopenia predicts greater risk of functional disability than sarcopenia: a longitudinal analysis of FraDySMex cohort study.The journal of nutrition, health & aging · 2024Article
- Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- The association of dietary acid load (DAL) with estimated skeletal muscle mass and bone mineral content: a cross-sectional study.BMC nutrition · 2023Article
- Effects of Muscles on Bone Metabolism-with a Focus on Myokines.Annals of geriatric medicine and research · 2022Article
- Association of decreased muscle mass with reduced bone mineral density in patients with Graves' disease.Endocrine · 2022Article
- The Role of Irisin in Exercise-Mediated Bone Health.Frontiers in cell and developmental biology · 2021Review
- Low muscle mass and body composition analysis in a group of postmenopausal women affected by primary Sjögren's syndrome.Reumatologia · 2021Article
- Muscle and bone mass in middle-aged women: role of menopausal status and physical activity.Journal of cachexia, sarcopenia and muscle · 2020Article
- Article
- The -839(A/C) Polymorphism in theJournal of the Endocrine Society · 2019Article
- Osteosarcopenia: A case of geroscience.Aging medicine (Milton (N.S.W)) · 2019Review
- Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.Nature communications · 2017Article
- Review
- Lean Mass and Body Fat Percentage Are Contradictory Predictors of Bone Mineral Density in Pre-Menopausal Pacific Island Women.Nutrients · 2016Article
- Inhibiting myostatin signaling prevents femoral trabecular bone loss and microarchitecture deterioration in diet-induced obese rats.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Relationship of sarcopenia and body composition with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.Clinical epigenetics · 2015Article
- Heritability of aerobic power of individuals in northeast Brazil.Biology of sport · 2014Article
- Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The purpose of this study was to investigate the relationship of fat mass (FM) and lean mass (LM) with bone mineral density (BMD) independent of genetic effects. We also assessed the extent to which genetic and environmental influences explain the associations between these phenotypes. Body composition and BMD were measured using dual-energy X-ray absorptiometry in 57 monozygotic and 92 same-sex dizygotic twin pairs, aged 23 to 31 years, chosen to represent a wide range of intrapair differences in body mass index (BMI; 0 to 15.2 kg/m(2)). Heritability estimates were adjusted for height and gender. In multiple linear regression analysis, intrapair differences in both FM and LM were independently associated with intrapair differences in BMD at most skeletal sites after adjustment for gender and differences in height. Within monozygotic and dizygotic pairs, LM was a significantly stronger predictor of whole-body BMD than FM (p < .01). Additive genetic factors explained 87% [95% confidence interval (CI) 80%-91%), 81% (95% CI 70%-88%), and 61% (95% CI 41%-75%) of the variation in whole-body BMD, LM, and FM, respectively. Additive genetic factors also accounted for 69% to 88% of the covariance between LM and BMD and for 42% to 72% of the covariance between FM and BMD depending on the skeletal site. The genetic correlation between LM and whole-body BMD (r(g) = 0.46, 95% CI 0.32-0.58) was greater than that of FM and whole-body BMD (r(g) = 0.25, 95% CI 0.05-0.42). In conclusion, our data indicate that peak BMD is influenced by acquired body weight as well as genetic factors. In young adulthood, LM and BMD may have more genes in common than do FM and BMD.
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Registered trials
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