ArticleLangenbeck's archives of surgery2010
Persistent symptomatic improvement in the majority of patients undergoing parathyroidectomy for primary hyperparathyroidism.
Article in Langenbeck's archives of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Improvement of sleep disturbance and insomnia following parathyroidectomy for primary hyperparathyroidism.World journal of surgery · 2014Trial
- Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism.Endocrine connections · 2025Article
- Primary Hyperparathyroidism in a 21 Year Old Patient of Turner Syndrome : A Rare Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Analysis of Time to Diagnosis and Outcomes Among Adults With Primary Hyperparathyroidism.JAMA network open · 2022Article
- Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.Journal of clinical medicine · 2022Article
- Stones, Bones, Groans, and Psychic Moans: Primary Hyperparathyroidism Presenting as Surgical Emergency.Cureus · 2019Article
- Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue.Journal of clinical medicine · 2019Article
- Surgical management of a giant parathyroid adenoma through minimal invasive parathyroidectomy. A case report.International journal of surgery case reports · 2017Article
- Primary hyperparathyroidism.Ulusal cerrahi dergisi · 2016Review
- Health-related quality of life is impaired in primary hyperparathyroidism and significantly improves after surgery: a prospective study using the 15D instrument.Endocrine connections · 2015Article
- Elevated parathyroid hormone after parathyroidectomy delays symptom improvement.The Journal of surgical research · 2014Article
- Timing of symptom improvement after parathyroidectomy for primary hyperparathyroidism.Surgery · 2013Article
- Perioperative management of delirium and dementia in the geriatric surgical patient.Langenbeck's archives of surgery · 2013Review
- Development of a new tool for assessing health-related quality of life in patients with primary hyperparathyroidism.Health and quality of life outcomes · 2013Article
- Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism.Langenbeck's archives of surgery · 2012Article
- Surgical endocrinology--update 2010.Langenbeck's archives of surgery · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParathyroidectomy for primary hyperparathyroidism (PHPT) is followed by a decrease in the severity of symptoms reported on the Pasieka's parathyroid symptoms score (PPSS) and SF-36 questionnaires. Some argue that such benefits are short-lived. This study investigates the severity of symptoms at more than 12 months after parathyroidectomy.
methodsA prospective database collected clinical/operative data on consecutive patients with PHPT. PPSS was calculated as the sum of the 13 parameters self-assessed using a visual analog scale. SF-36(v2) was analyzed using commercially available software (QualityMetric Inc., Lincoln, USA).
resultsOver 3-year interval, 166 patients (119 F/47 M, age 15-89 years) were operated for with PHPT (Ca 2.90 ± 0.25 mmol/L, PTH 21.64 ± 23.05 pmol/L). Their preoperative PPSS ranged 0-1,260 (median 413) and did not correlate with the severity of hypercalcemia. One hundred and seven patients responded when contacted by post at 18 ± 6 months postoperatively. Their postoperative PPSS was significantly lower (398 ± 226 to 231 ± 203, p < 0.001) and in 55 of 107 patients the severity of symptoms reduced by at least 50%. Most significant improvements were for mood (36 ± 33 vs. 16 ± 23), weakness/tiredness (37 ± 32 vs. 17 ± 23), irritability (35 ± 31 vs. 17 ± 21), and thirst (37 ± 32 vs. 18 ± 25; p < 0.0001). Physical and mental component scores of SF-36 questionnaire improved in patients whose PPSS decreased postoperatively.
conclusionSymptomatic benefits persist for at least 1 year after parathyroidectomy in the majority of patients with PHPT.
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Registered trials
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