ArticleRheumatology international2012
Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Decoding Nano-Bio Interactions: Gene Regulatory Networks in Advanced Drug Loading.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Gender inequality in osteoarthritis: a bioinformatics perspective.Clinical rheumatology · 2026Article
- Integrative transcriptomics-metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis.Frontiers in immunology · 2026Article
- Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism.Chinese medicine · 2025Article
- Application of metabolomics in the classification of traditional Chinese medicine syndromes in rheumatoid arthritis.Clinical rheumatology · 2025Article
- Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research.Genetics research · 2025Article
- Rheumatoid arthritis characteristics and classification of heat and cold patterns-an observational study.Heliyon · 2023Article
- Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis.Chinese medicine · 2022Article
- Novel research synergized by Chinese medicine pattern classification in rheumatoid arthritis.Clinical rheumatology · 2022Article
- Hot and Cold Theory: Evidence in Systems Biology.Advances in experimental medicine and biology · 2021Article
- Mizaj as an Index in Persian Traditional Medicine Index Could Associate with Sensitivity to the Radiation.Galen medical journal · 2020Article
- Unsupervised Learning and Multipartite Network Models: A Promising Approach for Understanding Traditional Medicine.Frontiers in pharmacology · 2020Review
- Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway.Drug design, development and therapy · 2020Article
- Bioinformatics analysis of differentially expressed genes involved in human developmental chondrogenesis.Medicine · 2019Article
- Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry.Molecules (Basel, Switzerland) · 2019Article
- Understanding Chinese Medicine Patterns of Rheumatoid Arthritis and Related Biomarkers.Medicines (Basel, Switzerland) · 2018Review
- Prediction of cold and heat patterns using anthropometric measures based on machine learning.Chinese journal of integrative medicine · 2018Article
- Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome.Oncotarget · 2017Article
- CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks.International journal of molecular sciences · 2017Article
- Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern.International journal of molecular sciences · 2016Article
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Authors and funding
8 authors.
Funding
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Abstract
The research is aimed to explore the distinct molecular signatures in discriminating the rheumatoid arthritis patients with traditional Chinese medicine (TCM) cold pattern and heat pattern. Twenty patients with typical TCM cold pattern and heat pattern were included. Microarray technology was used to reveal gene expression profiles in CD4+ T cells. The signal intensity of each expressed gene was globally normalized using the R statistics program. The ratio of cold pattern to heat pattern in patients with RA at more or less than 1:2 was taken as the differential gene expression criteria. Protein-protein interaction information for these genes from databases was searched, and the highly connected regions were detected by IPCA algorithm. The significant pathways were extracted from these subnetworks by Biological Network Gene Ontology tool. Twenty-nine genes differentially regulated between cold pattern and heat pattern were found. Among them, 7 genes were expressed significantly more in cold pattern. Biological network of protein-protein interaction information for these significant genes were searched and four highly connected regions were detected by IPCA algorithm to infer significant complexes or pathways in the biological network. Particularly, the cold pattern was related to Toll-like receptor signaling pathway. The following related pathways in heat pattern were included: Calcium signaling pathway; cell adhesion molecules; PPAR signaling pathway; fatty acid metabolism. These results suggest that better knowledge of the main biological processes involved at a given pattern in TCM might help to choose the most appropriate treatment.
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