ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2010
Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Application of (68)Ga-PRGD2 PET/CT for αvβ3-integrin imaging of myocardial infarction and stroke.Theranostics · 2014Trial
- Beyond perfusion: a review of peptide radiopharmaceuticals for cardiovascular imaging.Npj imaging · 2025Review
- Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging.Molecular imaging and biology · 2025Review
- [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Cardiac fibrosis in oncologic therapies.Current opinion in physiology · 2022Article
- Nuclear Molecular Imaging of Cardiac Remodeling after Myocardial Infarction.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target.Frontiers in cardiovascular medicine · 2022Review
- Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow.European journal of nuclear medicine and molecular imaging · 2021Article
- Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using aJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Molecular imaging of fibrosis: recent advances and future directions.The Journal of clinical investigation · 2019Review
- Playing slot to hitting the jackpot in molecular imaging: On probability of uncovering subcellular pathogenesis vs achieving clinical applicability.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- PET imaging ofEJNMMI research · 2018Article
- PET imaging in heart failure: the role of new tracers.Heart failure reviews · 2017Review
- Cardiac αHeart (British Cardiac Society) · 2017Article
- Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3.Theranostics · 2016Review
- Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- PET imaging of cardiac wound healing using a novel [68Ga]-labeled NGR probe in rat myocardial infarction.Molecular imaging and biology · 2015Article
- Imaging of inflammation and calcification in aortic stenosis.Current cardiology reports · 2013Review
- PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2.European journal of nuclear medicine and molecular imaging · 2012Article
- The year in molecular imaging.JACC. Cardiovascular imaging · 2012Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe clinical feasibility of noninvasive imaging of interstitial alterations after myocardial infarction (MI) was assessed using a technetium-99m-labeled RGD imaging peptide (RIP). In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB). METHODS AND
resultsTen patients underwent myocardial perfusion imaging (MPI) within the first week after MI. At 3 and 8 weeks after MI, RIP was administered intravenously and SPECT images acquired for interstitial imaging. RIP imaging was compared to initial MPI and to the extent of scar formation defined by late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR) imaging 1 year after MI. RIP uptake was observed in 7 of the 10 patients at both 3 and 8 weeks. Although, RIP uptake corresponded to areas of perfusion defects, it usually extended beyond the infarct zone to a variable extent; 2 of 7 patients showed tracer uptake throughout myocardium. In all positive cases, RIP uptake was similar to the extent of scar observed at 1 year by LGE-CMR imaging.
conclusionThis study demonstrates that RGD-based imaging early after MI may predict the eventual extent of scar formation, which often exceeds initial MPI deficit but colocalizes with LGE in CMR imaging performed subsequently.
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