ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2010
Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Prevalence of impaired flow-mediated epicardial vasodilation among different types of coronary flow regulation.The international journal of cardiovascular imaging · 2026Article
- Artifact-free quantitative cardiovascular PET/MR imaging: An impossible dream?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Quantification of PET Myocardial Blood Flow.Current cardiology reports · 2019Review
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- PET-measured longitudinal flow gradient correlates with invasive fractional flow reserve in CAD patients.European heart journal. Cardiovascular Imaging · 2017Article
- Mitochondrial-Targeted Molecular Imaging in Cardiac Disease.BioMed research international · 2017Review
- Positron Emission Tomography-Determined Hyperemic Flow, Myocardial Flow Reserve, and Flow Gradient-Quo Vadis?Frontiers in cardiovascular medicine · 2017Review
- Myocardial blood flow: Putting it into clinical perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.Diagnostics (Basel, Switzerland) · 2016Review
- Longitudinal myocardial blood flow gradient and CAD detection.Current cardiology reports · 2015Review
- Quantitative PET/CT measures of myocardial flow reserve and atherosclerosis for cardiac risk assessment and predicting adverse patient outcomes.Current cardiology reports · 2013Review
- Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- The influence of insulin resistance, obesity, and diabetes mellitus on vascular tone and myocardial blood flow.Current cardiology reports · 2012Review
- Anti-apolipoprotein A-1 IgG levels predict coronary artery calcification in obese but otherwise healthy individuals.Mediators of inflammation · 2012Article
- Vascular function of the peripheral and coronary circulation: worthwhile to assess their relation?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers.European journal of nuclear medicine and molecular imaging · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine whether epicardial structural disease may affect the manifestation of a longitudinal decrease in myocardial blood flow (MBF) or MBF difference during hyperemia in cardiovascular risk individuals, and its dependency on the flow increase. METHODS AND
resultsIn 54 cardiovascular risk individuals (at risk) and in 26 healthy controls, MBF was measured with (13)N-ammonia and PET/CT in mL/g/min at rest and during dipyridamole stimulation. Computed tomography coronary angiography (CTA) was performed using a 64-slice CT of a PET/CT system. Absolute MBFs during dipyridamole stimulation were mildly lower in the mid-distal than in the mid-LV myocardium in controls (2.20 ± .51 vs 2.29 ± .51, P < .0001), while it was more pronounced in at risk with normal and abnormal CTA (1.56 ± .42 vs 1.91 ± .46 and 1.18 ± .34 vs 1.51 ± .40 mL/g/min, respectively, P < .0001), resulting in a longitudinal MBF difference that was highest in at risk with normal CTA, intermediate in at risk abnormal CTA, and lowest in controls (.35 ± .16 and .22 ± .09 vs .09 ± .04 mL/g/min, respectively, P < .0001). On multivariate analysis, log-CCS and mid-LV hyperemic MBF increase, indicative of microvascular function, were independent predictors of the observed longitudinal MBF difference (P ≤ .004 by ANOVA).
conclusionsEpicardial structural disease and microvascular function are important determinants of an abnormal longitudinal MBF difference as determined with PET/CT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.