ArticleJournal of natural medicines2011
Protection of HT22 neuronal cells against glutamate toxicity mediated by the antioxidant activity of Pueraria candollei var. mirifica extracts.
Article in Journal of natural medicines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Article
- Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract ofInternational journal of environmental research and public health · 2022Article
- Bioimprinting as a Receptor for Detection of Kwakhurin.Biomolecules · 2022Article
- Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells.Current neuropharmacology · 2021Review
- Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro.Mycology · 2020Article
- Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect.Journal of traditional and complementary medicine · 2020Review
- Article
- Gas chromatography analysis with olfactometric detection (GC-O) as a useful methodology for chemical characterization of odorous compounds.Sensors (Basel, Switzerland) · 2013Review
- Medical applications of phytoestrogens from the Thai herb Pueraria mirifica.Frontiers of medicine · 2012Review
- Rhinacanthus nasutus extracts prevent glutamate and amyloid-β neurotoxicity in HT-22 mouse hippocampal cells: possible active compounds include lupeol, stigmasterol and β-sitosterol.International journal of molecular sciences · 2012Article
- Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death.Molecules (Basel, Switzerland) · 2011Article
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Authors and funding
5 authors.
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Abstract
Neuronal degeneration is known to be due to oxidative stress acting through a pathway involving the excessive activation of glutamate receptors. We studied the neuroprotection potential of an ethyl acetate-ethanol extract of Pueraria mirifica (P. candollei var. mirifica) root (PM extract). PM extract was evaluated for its antioxidant and neuroprotective activities against glutamate toxicity in mouse hippocampal HT22 neuronal cells. The extract at concentrations of 10 and 50 μg/ml exhibited considerable antioxidant activity with significant neuroprotection, based on the microscopic observations of cell morphology and the determination of cell viability and cell number. Studies of the possible mechanisms of action indicated that the neuroprotection exerted by PM extract was related to its scavenging activity against H(2)O(2) and related reactive oxygen species. High-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC) analyses showed that the extract contained daidzein and genistein as identified constituents, as well as additional components with antioxidant activity. While daidzein and genistein individually and in combination were observed not to be neuroprotective, we propose that the antioxidant and neuroprotective activities of PM extract are derived from the combined properties of its constituents.
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Registered trials
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