ArticleDigestive diseases and sciences2011
Gender- and age-related differences in muscular and nerve-mediated responses in human colon.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- Changes in neuromuscular structure and functions of human colon during ageing are region-dependent.Gut · 2019Article
- Gender-differences of in vitro colonic motility after chemo- and radiotherapy in humans.BMC pharmacology & toxicology · 2018Article
- Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility.British journal of pharmacology · 2013Article
- Translational neuropharmacology: the use of human isolated gastrointestinal tissues.British journal of pharmacology · 2013Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGender- and age-related differences in muscular and nerve-mediated responses in human colon are poorly characterized. We studied carbachol-induced motor responses and electrically evoked contractions in sigmoid circular muscle from adult and elderly patients of different gender.
methodsSigmoid colon segments were obtained from 24 men and 16 women undergoing left hemicolectomy for colon cancer. Isometric tension was measured on muscle strips exposed to increasing carbachol concentrations. The effects of atropine, guanethidine, L-nitro arginine methyl ester (L-NAME), and tetrodotoxin on electrically evoked contractions were also studied.
resultsFemale patients showed higher maximal response to carbachol than male patients, elderly females being the most sensitive to carbachol among all patient groups. Electrically evoked contractions were linearly related to stimulation frequency and abolished by tetrodotoxin. Electrically evoked contractions were significantly more pronounced in elderly male patients; they were reduced by atropine and guanethidine and increased by L-nitro arginine methyl ester in the presence of atropine and guanethidine (P < 0.05). The effect of L-NAME was most marked in elderly male patients and least pronounced in elderly females.
conclusionsThe response to carbachol and the role of nitrergic pathways differ according to age and gender; this may depend on muscarinic receptor upregulation or humoral factors affecting nitric oxide release, respectively.
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