ArticleDigestive diseases and sciences2011
Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Thymoquinone Ameliorates Gut Epithelial Injury by Suppressing the JNK Signaling Pathway Based on Its Anti-Oxidant Property.Food science & nutrition · 2025Article
- Advance on establishment of pathological model of ulcerative colitis.Frontiers in veterinary science · 2025Review
- Review
- An Update of Research Animal Models of Inflammatory Bowel Disease.TheScientificWorldJournal · 2021Review
- Nutraceutical Approach to Preventing Coronavirus Disease 2019 and Related Complications.Frontiers in immunology · 2021Review
- Volatile compounds of black cumin (Heliyon · 2020Article
- Review
- T-Bet Is Dependent on Stat-4 Inhibiting Acute Colitis but Not Stat-1 Using L4 Somatic Antigen ofTheScientificWorldJournal · 2018Article
- The Anti-Inflammatory Effect of Guchangzhixie-Pill by Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in an Ulcerative Colitis Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- The TNBS-induced colitis animal model: An overview.Annals of medicine and surgery (2012) · 2016Review
- Actions of probiotics on trinitrobenzenesulfonic acid-induced colitis in rats.BioMed research international · 2015Article
- Therapeutic effects of thymoquinone in a model of neuropathic pain.Current therapeutic research, clinical and experimental · 2014Article
- A review on chemical-induced inflammatory bowel disease models in rodents.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Review
- Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives.Journal of gastroenterology · 2014Review
- Protective effects of citicoline on TNBS-induced experimental colitis in rats.International journal of clinical and experimental medicine · 2014Article
- Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research.Gut pathogens · 2013Article
- Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors.PloS one · 2012Article
- Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects.The review of diabetic studies : RDSReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogenesis and treatment of ulcerative colitis remain poorly understood. The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on rats with colitis.
methodsExperimental colitis was induced with 1 mL trinitrobenzene sulfonic acid (TNBS) in 40% ethanol by intracolonic administration with 8-cm-long cannula under ether anesthesia to rats in colitis group and colitis + black cumin oil group. Rats in the control group were given saline at the same volume by intracolonic administration. Black cumin oil (BCO, Origo "100% natural Black Cumin Seed Oil," Turkey) was given to colitis + black cumin oil group by oral administration during 3 days, 5 min after colitis induction. Saline was given to control and colitis groups at the same volume by oral administration. At the end of the experiment, macroscopic lesions were scored and the degree of oxidant damage was evaluated by colonic total protein, sialic acid, malondialdehyde, and glutathione levels, collagen content, and tissue factor, superoxide dismutase, and myeloperoxidase activities. Tissues were also examined by histological and cytological analysis. Proinflammatory cytokines [tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6], lactate dehydrogenase activity, and triglyceride and cholesterol levels were analyzed in blood samples.
resultsWe found that black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis.
conclusionsBCO, by preventing inflammatory status in the blood, partly protected colonic tissue against experimental ulcerative colitis.
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