ReviewRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2010
Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma.
Review in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association of Depression with Subclinical Coronary Atherosclerosis: a Systematic Review.Journal of cardiovascular translational research · 2021Pooled it
- The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models.Translational psychiatry · 2012Pooled it
- Association Between Trajectories of Depressive Symptoms and Cardiovascular Disease in Elderly Chinese Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).Brain and behavior · 2025Article
- Potential influence of long-term medication on physical performance in the context of long-term rehabilitation process in soldiers: a retrospective cohort analysis.Frontiers in rehabilitation sciences · 2025Article
- The Relationship Between Cardiovascular Disease Risk and Major Depression.Noro psikiyatri arsivi · 2023Article
- Cardiorespiratory fitness and cardiovascular risk among in-patients with depression compared to healthy controls.Frontiers in psychiatry · 2023Article
- Cognitive impairment and depression after acute myocardial infarction: associations with ejection fraction and demographic characteristics.Acta neurologica Belgica · 2021Article
- Mood Disorders and Increased Risk of Noncommunicable Disease in Adults With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Prevalence and determinants of depressive symptoms in patients with Chagas cardiomyopathy and predominantly preserved cardiac function.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease.Current neuropharmacology · 2020Review
- Prospective Validation of the Decalogue, a Set of Doctor-Patient Communication Recommendations to Improve Patient Illness Experience and Mood States within a Hospital Cardiologic Ambulatory Setting.BioMed research international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease.
methodA review of the literature based on the PubMed database. DISCUSSION: Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors.
conclusionAlthough there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.