ArticlePloS one2010
Whole-genome sequencing reveals distinct mutational patterns in closely related laboratory and naturally propagated Francisella tularensis strains.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mutational Switch-Backs Can Accelerate Evolution ofFrontiers in microbiology · 2022Article
- Identification of an Attenuated Substrain ofPathogens (Basel, Switzerland) · 2021Article
- Virulence ofMicroorganisms · 2020Article
- A Single-Nucleotide Insertion in a Drug Transporter Gene Induces a Thermotolerance Phenotype in Gluconobacter frateurii by Increasing the NADPH/NADPApplied and environmental microbiology · 2018Article
- Article
- Investigation of Yersinia pestis Laboratory Adaptation through a Combined Genomics and Proteomics Approach.PloS one · 2015Article
- Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4.Infection and immunity · 2014Article
- Article
- Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.Infection and immunity · 2013Article
- The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection.BMC microbiology · 2013Article
- Genomic comparison between a virulent type A1 strain of Francisella tularensis and its attenuated O-antigen mutant.Journal of bacteriology · 2012Article
- A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.Infection and immunity · 2011Article
- Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation.PloS one · 2011Article
- Iron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killing.Infection and immunity · 2011Article
- Regulation of francisella tularensis virulence.Frontiers in microbiology · 2010Article
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5 authors.
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Abstract
The F. tularensis type A strain FSC198 from Slovakia and a second strain FSC043, which has attenuated virulence, are both considered to be derivatives of the North American F. tularensis type A strain SCHU S4. These strains have been propagated under different conditions: the FSC198 has undergone natural propagation in the environment, while the strain FSC043 has been cultivated on artificial media in laboratories. Here, we have compared the genome sequences of FSC198, FSC043, and SCHU S4 to explore the possibility that the contrasting propagation conditions may have resulted in different mutational patterns. We found four insertion/deletion events (INDELs) in the strain FSC043, as compared to the SCHU S4, while no single nucleotide polymorphisms (SNPs) or variable number of tandem repeats (VNTRs) were identified. This result contrasts with previously reported findings for the strain FSC198, where eight SNPs and three VNTR differences, but no INDELs exist as compared to the SCHU S4 strain. The mutations detected in the laboratory and naturally propagated type A strains, respectively, demonstrate distinct patterns supporting that analysis of mutational spectra might be a useful tool to reveal differences in past growth conditions. Such information may be useful to identify leads in a microbial forensic investigation.
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