ArticlePloS one2010
Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?Antioxidants (Basel, Switzerland) · 2019Review
- Prenatal epigenetics diets play protective roles against environmental pollution.Clinical epigenetics · 2019Review
- Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis.Neurotoxicology · 2018Article
- Association of Bone Turnover Levels with MTHFR Gene Polymorphisms among Pregnant Women in Wuhan, China.Current medical science · 2018Article
- Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study.Environmental health : a global access science source · 2017Article
- Estimation of lead in biological samples of oral cancer patients chewing smokeless tobacco products by ionic liquid-based microextraction in a single syringe system.Environmental science and pollution research international · 2015Article
- Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health.International journal of environmental research and public health · 2015Article
- Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.Environmental health perspectives · 2014Article
- ALAD genotypes and blood lead levels of neonates and children from e-waste exposure in Guiyu, China.Environmental science and pollution research international · 2014Article
- Elevated blood lead levels among unskilled construction workers in Jimma, Ethiopia.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Association of body iron status with the risk of premature acute myocardial infarction in a Pakistani population.PloS one · 2013Article
- Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population.PloS one · 2013Article
- Association of homocysteine levels with blood lead levels and micronutrients in the US general population.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2012Article
- Relationship between vitamin B12, folate and homocysteine levels and H. pylori infection in patients with functional dyspepsia: a cross-section study.BMC research notes · 2012Article
- Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan. METHODOLOGY/PRINCIPAL
findingsIn a cross sectional survey, 872 healthy adults (355 males, 517 females; age 18-60 years) were recruited from a low income urban population of Karachi. Fasting venous blood was obtained and assessed for blood Pb and plasma/serum homocysteine, folate, pyridoxal phosphate (PLP, a coenzymic form of vitamin B6) and vitamin B12. The study population had median (IQR) blood Pb of 10.82 microg/dL (8.29-13.60). Prevalence of high blood Pb (levels>10 microg/dL) was higher in males compared to females (62.5% males vs 56% females; p value=0.05). Mean+/-SD/median (IQR) value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13+/-11.2 micromol/L vs 13.28+/-9.7micromol/L/13.15 (10.33-17.81) micromol/L vs 11.09 (8.65 14.31) micromol/L (p value<0.001). Daily consumption of fruit juice had a positive influence on both levels of plasma homocysteine and blood Pb. Compared with the lowest quartile of blood Pb, the OR for hyperhomocysteinemia was 1.69 (95% CI, 1.00 to 2.85) for the fourth quartile when the model was adjusted for age, gender, folate and vitamin B12. CONCLUSIONS/SIGNIFICANCE: This study showed a relationship between blood Pb and hyperhomocysteinemia in a general population of Karachi, Pakistan. The harmful effect of Pb on cardiovascular system could be due to its association with hyperhomocysteinemia.
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