ArticleNature cell biology2010
Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing.
Article in Nature cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Cell membrane asymmetries and cellular aging.The Biochemical journal · 2025Review
- PIFiA: self-supervised approach for protein functional annotation from single-cell imaging data.Molecular systems biology · 2024Article
- Novel ABC Transporter Associated with Fluconazole Resistance in Aging ofJournal of fungi (Basel, Switzerland) · 2022Article
- Review
- Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Emerging roles for sphingolipids in cellular aging.Current genetics · 2018Review
- Recent insights into the cellular and molecular determinants of aging.Journal of cell science · 2018Review
- Article
- Sphingolipids facilitate age asymmetry of membrane proteins in dividing yeast cells.Molecular biology of the cell · 2017Article
- Efflux Pump Control Alters Synthetic Gene Circuit Function.ACS synthetic biology · 2016Article
- Evidence for the hallmarks of human aging in replicatively aging yeast.Microbial cell (Graz, Austria) · 2016Review
- Article
- Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model.Scientific reports · 2015Article
- Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Electrochemical regulation of budding yeast polarity.PLoS biology · 2014Article
- Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Article
- Spatiotemporal analysis of organelle and macromolecular complex inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Organelle segregation during mitosis: lessons from asymmetrically dividing cells.The Journal of cell biology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cellular ageing is known to correlate with the accumulation of many harmful agents, but it is unclear whether ageing can also result from the deterioration of components that are beneficial to the cell, but have a low rate of renewal. Here, we report a group of plasma membrane-associated transporters in yeast, belonging to the multidrug resistance (MDR) protein families, that may represent the latter type of ageing determinants. During the division of a yeast cell, newly synthesized transporter proteins are deposited mostly into the growing bud, whereas previously synthesized MDR proteins remain tightly associated with the mother cortex. Thus, the new and old pools of membrane-bound MDR proteins are spatially segregated during yeast asymmetric cell division, with the older pool stably inherited by the ageing mother. A model based on the observed dynamics of MDR protein inheritance and turnover predicted a decline in MDR activity as the mother cell advances in replicative age. As MDR proteins have crucial roles in cellular metabolism, detoxification and stress response, their collective decline may lead to fitness loss at an advanced age. Supporting this hypothesis, mutants lacking certain MDR genes exhibited a reduced replicative lifespan (RLS), whereas introduction of only one extra copy of these MDR genes extended RLS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.