Evidence map›Paper›PMID 20657466›Full record

ArticleMolecules (Basel, Switzerland)2010

Automated synthesis of a 96 product-sized library of triazole derivatives using a solid phase supported copper catalyst.

Ibtissem Jlalia, Claire Beauvineau, Sophie Beauvière, Esra Onen, Marie Aufort, Aymeric Beauvineau, Eihab Khaba, Jean Herscovici, Faouzi Meganem, Christian Girard

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ibtissem JlaliaLaboratoire de Pharmacologie Chimique et Génétique (UMR 8151 CNRS, U 1022 INSERM, IFR 2769), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech; 11, rue Pierre et Marie Curie, 75005 Paris, France. ibtissemj@yahoo.fr
Claire Beauvineau
Sophie Beauvière
Esra Onen
Marie Aufort
Aymeric Beauvineau
Eihab Khaba
Jean Herscovici
Faouzi Meganem
Christian Girard

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.

Indexed as

AutomationCatalysisCombinatorial Chemistry TechniquesCopperFiltrationSmall Molecule LibrariesTriazolesCopperSmall Molecule LibrariesTriazoles

Identifiers

PMID20657466
PMCPMC6257452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.