Evidence map›Paper›PMID 20657280›Full record

ReviewCurrent opinion in clinical nutrition and metabolic care2010

Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research.

Xin Zhou, Maren S Fragala, Janet E McElhaney, George A Kuchel

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in clinical nutrition and metabolic care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 5 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xin ZhouUConn Center on Aging, University of Connecticut Health Center, 263 Farmington, Farmington, CT 06030-5215, USA.
Maren S Fragala
Janet E McElhaney
George A Kuchel
University of Connecticut · USUConn Health · US

Funding

T-Cell Responses Predict Influenza Risk in Older AdultsR01AI068265 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCELHANEY, JANET E. · 2005 to 2010
$2.3M
Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail ElderlyR01AG028657 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUCHEL, GEORGE A · 2007 to 2011
$1.6M
NIAID NIH HHS R01 AI068265NIAID NIH HHS R01AI068265NIA NIH HHS R01 AG028657NIA NIH HHS R01AG028657
6 · The paper itself

Abstract

purpose of reviewTo provide clinical investigators with an understanding of factors to consider when wishing to add cytokine and inflammatory marker measurements to their studies. RECENT

findingsInflammation involves complex and coordinated responses of the immune system to tissue damage. In the absence of tools to routinely assess inflammation within living tissues, measurements of humoral factors such as cytokines and other inflammatory mediators or markers can provide predictive clinical information and insights into disease mechanisms. Historically, enzyme-linked immunosorbent assays (ELISAs) became the gold standard, yet this approach of measuring a single protein in each sample limits the amount of information which can be obtained from limited amounts of human sample. In recent years, commercially available multiplex technologies which detect large numbers of proteins in a limited volume have provided investigators with opportunities to begin addressing the complexity of inflammatory responses. Nevertheless, great attention needs to be paid to many aspects of study design, sample collection, sample measurement and data analysis. These considerations are especially significant when using technologies for which experience remains limited. SUMMARY: Whereas measurements of peripheral levels of inflammatory markers can add important mechanistic elements to human subject research, careful attention to conceptual and methodological considerations is essential, especially when using novel technologies.

Indexed as

Biological AssayBiomarkersBiomedical ResearchCytokinesEnzyme-Linked Immunosorbent AssayHumansInflammationInflammation MediatorsBiomarkersCytokinesInflammation Mediators

Identifiers

PMID20657280
PMCPMC2955626
OpenAlexW2011136641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.