ArticleEukaryotic cell2010
Pseudohyphal regulation by the transcription factor Rfg1p in Candida albicans.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Identification of the ADH gene family in Trichosporon asahii and the role of TaADH_like in pathogenicity and fluconazole resistance.BMC genomics · 2025Article
- Antifungal activities of Equol againstVirulence · 2024Article
- Examining the effects of BRG1 over-expression on Candida albicans strains growing as pseudohyphae.Folia microbiologica · 2023Article
- Constitutive ALS3 expression in Candida albicans enhances adhesion and biofilm formation of efg1, but not cph1 mutant strains.PloS one · 2023Article
- Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care dressing.Bioelectrochemistry (Amsterdam, Netherlands) · 2021Article
- Geldanamycin-Induced Morphological Changes Require Candida albicans Hyphal Growth Regulatory Machinery.Mycopathologia · 2021Article
- AJournal of fungi (Basel, Switzerland) · 2021Article
- The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021Review
- Article
- Examination of the pathogenic potential of Candida albicans filamentous cells in an animal model of haematogenously disseminated candidiasis.FEMS yeast research · 2016Article
- A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence.PLoS pathogens · 2013Article
- Candida albicans white and opaque cells undergo distinct programs of filamentous growth.PLoS pathogens · 2013Article
- BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence.Molecular microbiology · 2012Article
- Investigating the function of Ddr48p in Candida albicans.Eukaryotic cell · 2012Article
- A MAP kinase pathway is implicated in the pseudohyphal induction by hydrogen peroxide in Candica albicans.Molecules and cells · 2012Article
- Article
- Candida albicans adhesin Als3p is dispensable for virulence in the mouse model of disseminated candidiasis.Microbiology (Reading, England) · 2011Article
- Regulatory circuitry governing fungal development, drug resistance, and disease.Microbiology and molecular biology reviews : MMBR · 2011Review
- The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersion.Eukaryotic cell · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
The opportunistic human fungal pathogen Candida albicans is a major cause of nosocomial infections. One of the fundamental features of C. albicans pathogenesis is the yeast-to-hypha transition. Hypha formation is controlled positively by transcription factors such as Efg1p and Cph1p, which are required for hyphal growth, and negatively by Tup1p, Rfg1p, and Nrg1p. Previous work by our group has shown that modulating NRG1 gene expression, hence altering morphology, is intimately linked to the capacity of C. albicans to cause disease. To further dissect these virulence mechanisms, we employed the same strategy to analyze the role of Rfg1p in filamentation and virulence. Studies using a tet-RFG1 strain revealed that RFG1 overexpression does not inhibit hypha formation in vitro or in the mouse model of hematogenously disseminated candidiasis. Interestingly, RFG1 overexpression drives formation of pseudohyphae under yeast growth conditions-a phenotype similar to that of C. albicans strains with mutations in one of several mitotic regulatory genes. Complementation assays and real-time PCR analysis indicate that, although the morphology of the tet-RFG1 strain resembles that of the mitotic regulator mutants, Rfg1p overexpression does not impact expression of these genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.