ArticleAmerican journal of physiology. Lung cellular and molecular physiology2010
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
Article in American journal of physiology. Lung cellular and molecular physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis.BioMed research international · 2021Pooled it
- Bim Expression Influences Choroidal Endothelial Cell Characteristics and Their Response to Therapeutic Intervention.International journal of molecular sciences · 2024Article
- Article
- Article
- Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities.Frontiers in cell and developmental biology · 2021Article
- Article
- Bcl-2 Expression in Pericytes and Astrocytes Impacts Vascular Development and Homeostasis.Scientific reports · 2019Article
- Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition.Journal of biophotonics · 2018Article
- Endothelial cell apoptosis in angiogenesis and vessel regression.Cellular and molecular life sciences : CMLS · 2017Review
- Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature.PloS one · 2017Article
- The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma.International journal of molecular sciences · 2015Review
- Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization.PloS one · 2015Article
- Organ specific optical imaging of mitochondrial redox state in a rodent model of hereditary hemorrhagic telangiectasia-1.Journal of biophotonics · 2014Article
- Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.PloS one · 2014Article
- Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes.American journal of physiology. Renal physiology · 2013Article
- Modulation of vascular cell function by bim expression.International journal of cell biology · 2013Article
- BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.American journal of physiology. Renal physiology · 2012Article
- Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia.Developmental biology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Integration of cell adhesive, survival, and proliferative processes is essential for capillary morphogenesis of endothelial cells (EC) in vitro and vascular development and function in vivo. Unfortunately, the molecular and cellular mechanisms that impact these processes are poorly defined. Here we examined how lack of bim and/or bcl-2 expression impact lung EC function. The absence of bcl-2 or bim had a significant impact on EC adhesion and migration. Lack of bcl-2 expression decreased lung EC migration, whereas lack of bim expression increased migration compared with their wild-type counterparts. Decreased adhesion to fibronectin and vitronectin was observed in both bcl-2-/- and bim-/- lung EC, with bcl-2-/- EC having very little adhesion to either matrix protein. Capillary morphogenesis was greatly diminished in bcl-2-/- EC, which correlated with decreased lung alveolarization in vivo, an angiogenesis-dependent process. We also observed aberrant production of extracellular matrix proteins, eNOS expression, and nitric oxide production in bcl-2-/- lung EC, which could contribute to inability to undergo capillary morphogenesis. The changes in cell adhesion and migration noted in the absence of bim or bcl-2 were independent of their impact on apoptosis. We observed no significant affect on the steady-state rate of apoptosis of lung EC in the absence of bim or bcl-2. Thus, bcl-2 family members, bim and bcl-2, play a central role in modulation of EC proangiogenic properties, which goes beyond their role as simple mediators of mitochondrial homeostasis and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.