ArticleJournal of the Royal Society, Interface2011
The radial growth phase of malignant melanoma: multi-phase modelling, numerical simulations and linear stability analysis.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 88 citations in OpenAlex.
- Predictive models of melanoma metastasis based on dermatoscopy in an international retrospective human reader study.Nature communications · 2025Article
- Spatial Segregation Across Travelling Fronts in Individual-Based and Continuum Models for the Growth of Heterogeneous Cell Populations.Bulletin of mathematical biology · 2025Article
- Phenotype structuring in collective cell migration: a tutorial of mathematical models and methods.Journal of mathematical biology · 2025Review
- Review
- Review
- 3D Melanoma Cocultures as Improved Models for Nanoparticle-Mediated Delivery of RNA to Tumors.Cells · 2022Article
- Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.Scientific reports · 2021Article
- Review
- The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma.Frontiers in oncology · 2021Review
- An integrative network-driven pipeline for systematic identification of lncRNA-associated regulatory network motifs in metastatic melanoma.BMC bioinformatics · 2020Article
- Computational models of melanoma.Theoretical biology & medical modelling · 2020Review
- Uncertainty quantification on a spatial Markov-chain model for the progression of skin cancer.Journal of mathematical biology · 2020Article
- Bridging the gap between individual-based and continuum models of growing cell populations.Journal of mathematical biology · 2020Article
- Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device.Micromachines · 2019Article
- Stability and Roughness of Interfaces in Mechanically Regulated Tissues.Physical review letters · 2018Article
- Nonlinear studies of tumor morphological stability using a two-fluid flow model.Journal of mathematical biology · 2018Article
- Incompressible Limit of a Mechanical Model for Tissue Growth with Non-Overlapping Constraint.Communications in mathematical sciences · 2017Article
- Tissue-scale, personalized modeling and simulation of prostate cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Adhesion-induced instabilities and pattern formation in thin films of elastomers and gels.The European physical journal. E, Soft matter · 2015Article
- Metastatic melanoma cells evade immune detection by silencing STAT1.International journal of molecular sciences · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous melanoma is disproportionately lethal despite its relatively low incidence and its potential for cure in the early stages. The aim of this study is to foster understanding of the role of microstructure on the occurrence of morphological changes in diseased skin during melanoma evolution. The authors propose a biomechanical analysis of its radial growth phase, investigating the role of intercellular/stromal connections on the initial stages of epidermis invasion. The radial growth phase of a primary melanoma is modelled within the multi-phase theory of mixtures, reproducing the mechanical behaviour of the skin layers and of the epidermal-dermal junction. The theoretical analysis takes into account those cellular processes that have been experimentally observed to disrupt homeostasis in normal epidermis. Numerical simulations demonstrate that the loss of adhesiveness of the melanoma cells both to the basal laminae, caused by deregulation mechanisms of adherent junctions, and to adjacent keratynocytes, consequent to a downregulation of E-cadherin, are the fundamental biomechanical features for promoting tumour initiation. Finally, the authors provide the mathematical proof of a long wavelength instability of the tumour front during the early stages of melanoma invasion. These results open the perspective to correlate the early morphology of a growing melanoma with the biomechanical characteristics of its micro-environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.