ArticleBrain, behavior, and immunity2011
Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.
Article in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Review
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- The multifaceted impact of stress on immune function.Molecular biology reports · 2025Review
- SIR+ models: accounting for interaction-dependent disease susceptibility in the planning of public health interventions.Scientific reports · 2024Article
- A Review of the Effects of Some Extrinsic Factors on Mice Used in Research.Comparative medicine · 2023Review
- Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms.Brain, behavior, and immunity · 2021Review
- Review
- A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack.Open biology · 2020Article
- From early adversities to immune activation in psychiatric disorders: the role of the sympathetic nervous system.Clinical and experimental immunology · 2019Review
- A Pilot Study Using a Multistaged Integrated Analysis of Gene Expression and Methylation to Evaluate Mechanisms for Evening Fatigue in Women Who Received Chemotherapy for Breast Cancer.Biological research for nursing · 2019Article
- Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress.Frontiers in behavioral neuroscience · 2018Article
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.Biological research for nursing · 2016Article
- Glucocorticoids enhance the in vivo migratory response of human monocytes.Brain, behavior, and immunity · 2016Article
- Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.Translational psychiatry · 2014Review
- Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).Molecular psychiatry · 2013Article
- β-Adrenergic receptor mediated increases in activation and function of natural killer cells following repeated social disruption.Brain, behavior, and immunity · 2012Article
- Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.Journal of neuroimmunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic cells (DCs) sample their surrounding microenvironment and consequently send immunogenic or regulatory signals to T cells during DC/T cell interactions, shaping the primary adaptive immune response to infection. The microenvironment resulting from repeated social defeat increases DC co-stimulatory molecule expression and primes DCs for enhanced cytokine responses in vitro. In this study, we show that social disruption stress (SDR) results in the generation of immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the adoptive transfer of DCs from SDR mice had significantly increased numbers of D(b)NP(366-74)CD8(+) T cells, increased IFN-γ and IFN-α mRNA, and decreased influenza M1 mRNA expression in the lung during the peak primary response (9 days post-infection), compared to mice that received DCs from naïve mice. These data demonstrate that repeated social defeat is a significant environmental influence on immunogenic DC activation and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.