ArticleGene2010
Evolutionary conservation of amino acid composition in paralogous insect vitellogenins.
Article in Gene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Evaluation of Nutritional Quality and Oxidation Stability of Fermented Edible Insects.Foods (Basel, Switzerland) · 2025Article
- Article
- Detecting false positive sequence homology: a machine learning approach.BMC bioinformatics · 2016Article
- Analyses of the general rule on residue pair frequencies in local amino acid sequences of soluble, ordered proteins.Protein science : a publication of the Protein Society · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Comparison of paralogous vitellogenins in 10 insect species representing six orders showed a remarkable degree of conservation of amino acid composition in spite of sequence differences. For example, the correlation between the percentages of the 20 amino acids in two vitellogenins from the beetle Tribolium castaneum was 0.975, even though the two amino acid sequences differed from each other at 49.4% of sites. There was a positive correlation between the frequency of occurrence of reciprocal pairs of amino acids in more distantly related paralogs, and this correlation was generally strongest when both of the amino acids in the pair were nutritionally essential. These results imply that conservation of amino acid composition occurs through amino acid replacements that result in a balanced loss and gain of each amino acid residue. Thus insect vitellogenins seem to be subject to an unusual kind of purifying selection, where the amino acid content is conserved rather than the sequence per se, selection apparently arising from the nutritional needs of the developing embryo appears to be responsible for maintaining the balance of amino acids.
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