ArticleBehavioural brain research2011
Novelty seeking, incentive salience and acquisition of cocaine self-administration in the rat.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 123 citations in OpenAlex.
- Article
- Article
- Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.Genes, brain, and behavior · 2025Article
- Implementations of sign- and goal-tracking behavior in humans: A scoping review.Cognitive, affective & behavioral neuroscience · 2025Article
- Resting-state brain activation patterns and network topology distinguish human sign and goal trackers.Translational psychiatry · 2024Article
- Self-administration acquisition latency predicts locomotor sensitivity to cocaine in male rats.Behavioural brain research · 2024Article
- Leveraging individual differences in cue-reward learning to investigate the psychological and neural basis of shared psychiatric symptomatology: The sign-tracker/goal-tracker model.Behavioral neuroscience · 2024Review
- Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.bioRxiv : the preprint server for biology · 2024Article
- Understanding the shift to compulsion in addiction: insights from personality traits, social factors, and neurobiology.Frontiers in psychology · 2024Review
- The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis-related phenotypes.Physiology & behavior · 2023Article
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- A mechanical task for measuring sign- and goal-tracking in humans: A proof-of-concept study.Behavioural brain research · 2023Article
- Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.Psychopharmacology · 2022Article
- Novelty preference does not predict trait cocaine behaviors in male rats.Addiction neuroscience · 2022Article
- Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum.Cell reports · 2022Article
- Melatonin attenuates morphine-induced conditioned place preference in Wistar rats.Brain and behavior · 2021Article
- Comment on Pohorala et al.: Sign-tracking as a predictor of addiction vulnerability.Psychopharmacology · 2021Article
- Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.Drug and alcohol dependence · 2021Review
- Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats.Scientific reports · 2021Article
- Effects of Social Isolation on Perineuronal Nets in the Amygdala Following a Reward Omission Task in Female Rats.Molecular neurobiology · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It has been suggested that incentive salience plays a major role in drug abuse and the development of addiction. Additionally, novelty seeking has been identified as a significant risk factor for drug abuse. However, how differences in the readiness to attribute incentive salience relate to novelty seeking and drug abuse vulnerability has not been explored. The present experiments examined how individual differences in incentive salience attribution relate to novelty seeking and acquisition of cocaine self-administration in a preclinical model. Rats were first assessed in an inescapable novelty task and a novelty place preference task (measures of novelty seeking), followed by a Pavlovian conditioned approach task for food (a measure of incentive salience attribution). Rats then were trained to self-administer cocaine (0.3 or 1.0 mg/kg/infusion) using an autoshaping procedure. The results demonstrate that animals that attributed incentive salience to a food-associated cue were higher novelty seekers and acquired cocaine self-administration more quickly at the lower dose. The results suggest that novelty-seeking behavior may be a mediator of incentive salience attribution and that incentive salience magnitude may be an indicator of drug reward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.