ArticleBiophysical journal2010
Thermodynamics of polyethylenimine-DNA binding and DNA condensation.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Revealing two distinct molecular binding modes in polyethyleneimine-DNA polyplexes using infrared spectroscopy.Soft matter · 2025Article
- The Impact of Using Different Cationic Polymers on the Formation of Efficient Lipopolyplexes for pDNA Delivery.International journal of nanomedicine · 2025Article
- Hybrid fibrous architectures-mediated gene transfer by pDNA nanoparticles into macrophages.Heliyon · 2024Article
- Inhibitors of Polyphosphate and Neutrophil Extracellular Traps.Seminars in thrombosis and hemostasis · 2024Review
- Closing the Gap between Experiment and Simulation─A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine.Molecular pharmaceutics · 2024Article
- Structural DNA nanotechnology at the nexus of next-generation bio-applications: challenges and perspectives.Nanoscale advances · 2024Review
- Antibiofilm Activity of PEGylated Branched Polyethylenimine.ACS omega · 2022Article
- Experimental study of a nanoscale translocation ratchet.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- The biological applications of DNA nanomaterials: current challenges and future directions.Signal transduction and targeted therapy · 2021Review
- Fundamental and Practical Aspects in the Formulation of Colloidal Polyelectrolyte Complexes of Chitosan and siRNA.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Effects of Chain Length of Chitosan Oligosaccharides on Solution Properties and Complexation with siRNA.Polymers · 2019Article
- Molecular Weight-Dependent Activity of Aminated Poly(α)glutamates as siRNA Nanocarriers.Polymers · 2018Article
- Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through Affinity Constants, Drug Release Kinetics, and Conformational Changes.Scientia pharmaceutica · 2017Article
- Article
- Targeting HPV-infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine.Bioengineering & translational medicine · 2016Article
- Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.Biomaterials · 2014Article
- Lipid nanoparticles for short interfering RNA delivery.Advances in genetics · 2014Review
- Independent versus cooperative binding in polyethylenimine-DNA and Poly(L-lysine)-DNA polyplexes.The journal of physical chemistry. B · 2013Article
- The novel albumin-chitosan core-shell nanoparticles for gene delivery: preparation, optimization and cell uptake investigation.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this study, polyethylenimine (PEI) binding to DNA was examined by isothermal titration calorimetry. Two types of binding modes were found to describe the interactions between these polyelectrolytes in buffers and in water. One type of binding involves PEI binding to the DNA groove because the enthalpy change of this binding mode is positive, and PEI is deprotonated to bind to DNA. Another likely binding mode involves external binding of PEI to the DNA phosphate backbone, accompanied with DNA condensation. The enthalpy change is negative and PEI is protonated when it binds to DNA in this mode. The intrinsic enthalpy change of first binding mode is 1.1 kJ/mol and -0.88 kJ/mol for the second binding mode. This result implies that the PEI is rearranged from the groove to the phosphate backbone of DNA when DNA is condensed. The mechanism of DNA condensation caused by PEI is discussed in this study.
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