ArticleBiophysical journal2010
Allosteric cross talk between cadherin extracellular domains.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Light-controlled synthetic communication networks via paired connexon nanopores.Nature communications · 2025Article
- Characterizing interactions in E-cadherin assemblages.Biophysical journal · 2023Article
- Engineering the Interactions of Classical Cadherin Cell-Cell Adhesion Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inside-out regulation of E-cadherin conformation and adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Arrhythmogenic cardiomyopathy related DSG2 mutations affect desmosomal cadherin binding kinetics.Scientific reports · 2017Article
- Cis and Trans Cooperativity of E-Cadherin Mediates Adhesion in Biomimetic Lipid Droplets.Biophysical journal · 2016Article
- Article
- Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand.Journal of the Royal Society, Interface · 2014Article
- Metastasis review: from bench to bedside.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Tuning the kinetics of cadherin adhesion.The Journal of investigative dermatology · 2013Review
- Mutation screen and RNA analysis disclose the changed splicing of the E-cadherin transcription in gastric cancer.Familial cancer · 2013Article
- Novel CDH1 germline mutations identified in Chinese gastric cancer patients.World journal of gastroenterology · 2013Article
- Ideal, catch, and slip bonds in cadherin adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cadherin recognition and adhesion.Current opinion in cell biology · 2012Review
- Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion.Molecular biology of the cell · 2012Article
- Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.Physiological reviews · 2011Review
- Modulation of E-cadherin function and dysfunction by N-glycosylation.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atomic force microscopy and surface force apparatus measurements determined the functional impact of the cadherin point mutation W2A and domain deletion mutations on C-cadherin binding signatures. Direct comparison of results obtained using both experimental approaches demonstrates that C-cadherin ectodomains form multiple independent bonds that require different structural regions. The results presented reveal significant interdomain cross talk. They further demonstrate that the mutation W2A not only abolishes adhesion between N-terminal domains, but allosterically modulates other binding states that require functional domains distal to the N-terminal binding site. Such allosteric effects may play a prominent role in modulating adhesion by Type I classic cadherins, cadherin oligomerization at junctional contacts, and propagation of binding information to the cytoplasmic region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.