ArticleBiophysical journal2010
The role of cell contraction and adhesion in dictyostelium motility.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- The cellular slime mold Fonticula alba forms a dynamic, multicellular collective while feeding on bacteria.Current biology : CB · 2022Article
- Macropinocytosis and Cell Migration: Don't Drink and Drive….Sub-cellular biochemistry · 2022Article
- Article
- Collective motility and mechanical waves in cell clusters.The European physical journal. E, Soft matter · 2021Article
- Cell Motility and Cancer.Cancers · 2020Review
- MMP-2 and Notch signal pathway regulate migration of adipose-derived stem cells and chondrocytes in co-culture systems.Cell proliferation · 2017Article
- Discrete Modeling of Amoeboid Locomotion and Chemotaxis in Dictyostelium discoideum by Tracking Pseudopodium Growth Direction.Scientific reports · 2017Article
- Article
- Non-model model organisms.BMC biology · 2017Article
- WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.The Journal of cell biology · 2017Article
- Center or periphery? Modeling the effects of focal adhesion placement during cell spreading.PloS one · 2017Article
- A simple force-motion relation for migrating cells revealed by multipole analysis of traction stress.Biophysical journal · 2014Article
- Article
- Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells.Journal of muscle research and cell motility · 2012Article
- Coupling actin flow, adhesion, and morphology in a computational cell motility model.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.PLoS computational biology · 2012Article
- An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells.Cellular and molecular bioengineering · 2011Article
- Activated membrane patches guide chemotactic cell motility.PLoS computational biology · 2011Article
- Nhe1 is essential for potassium but not calcium facilitation of cell motility and the monovalent cation requirement for chemotactic orientation in Dictyostelium discoideum.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The crawling motion of Dictyostelium discoideum on substrata involves a number of coordinated events including cell contractions and cell protrusions. The mechanical forces exerted on the substratum during these contractions have recently been quantified using traction force experiments. Based on the results from these experiments, we present a biomechanical model of the contraction phase of Dictyostelium discoideum motility with an emphasis on the adhesive properties of the cell-substratum contact. Our model assumes that the cell contracts at a constant rate and is bound to the substratum by adhesive bridges that are modeled as elastic springs. These bridges are established at a spatially uniform rate while detachment occurs at a spatially varying, load-dependent rate. Using Monte Carlo simulations and assuming a rigid substratum, we find that the cell speed depends only weakly on the detachment kinetics of the cell-substratum interface, in agreement with experimental data. By varying the parameters that control the adhesive and contractile properties of the cell, we are able to make testable predictions. We also extend our model to include a flexible substrate and show that our model is able to produce substratum deformations and force patterns that are quantitatively and qualitatively in agreement with experimental data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.