ArticleGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2010
Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice.
Article in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries.GeroScience · 2022Article
- Consequences of Both Coxsackievirus B4 and Type 1 Diabetes on Female Non-Obese Diabetic Mouse Kidneys.Microorganisms · 2021Article
- Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-Obese Diabetic Mice Before Establishment of Diabetes.Viral immunology · 2020Article
- Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome.Scientific reports · 2017Article
- Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats.Iranian journal of basic medical sciences · 2017Article
- Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes.Aging · 2016Article
- Elevated systolic blood pressure in male GH transgenic mice is age dependent.Endocrinology · 2014Article
- The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice.Histology and histopathology · 2013Article
- GH and IGF1: roles in energy metabolism of long-living GH mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Effects of long-term experimental diabetes on adrenal gland growth and phosphoribosyl pyrophosphate formation in growth hormone-deficient dwarf rats.International journal of experimental pathology · 2012Article
- Growth hormone, inflammation and aging.Pathobiology of aging & age related diseases · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveBovine growth hormone (bGH) transgenic mice develop severe kidney damage. This damage may be due, at least in part, to changes in gene expression. Identification of genes with altered expression in the bGH kidney may identify mechanisms leading to damage in this system that may also be relevant to other models of kidney damage.
designcDNA subtraction libraries, northern blot analyses, microarray analyses and real-time reverse transcription polymerase chain reaction (RT/PCR) assays were used to identify and verify specific genes exhibiting differential RNA expression between kidneys of bGH mice and their non-transgenic (NT) littermates.
resultsImmunoglobulins were the vast majority of genes identified by the cDNA subtractions and the microarray analyses as being up-regulated in bGH. Several glycoprotein genes and inflammation-related genes also showed increased RNA expression in the bGH kidney. In contrast, only a few genes were identified as being significantly down-regulated in the bGH kidney. The most notable decrease in RNA expression was for the gene encoding kidney androgen-regulated protein.
conclusionsA number of genes were identified as being differentially expressed in the bGH kidney. Inclusion of two groups, immunoglobulins and inflammation-related genes, suggests a role of the immune system in bGH kidney damage.
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Registered trials
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