Evidence map›Paper›PMID 20655236›Full record

ArticleBioorganic & medicinal chemistry2010

Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.

Sanjib Bhattacharyya, Haiying Zhou, Derrick R Seiner, Kent S Gates

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Filtering through the role of NRF2 in kidney disease.Archives of pharmacal research · 2020
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sanjib BhattacharyyaDepartment of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
Haiying Zhou
Derrick R Seiner
Kent S Gates
University of Missouri · US

Funding

DNA ALKYLATION BY THE ANTITUMOR ANTIBIOTIC LEINAMYCINR01CA083925 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GATES, KENT S · 2000 to 2009
$1.6M
Chemical and Biological Mechanisms of LeinamycinR01CA119131 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GATES, KENT S · 2006 to 2010
$1.3M
NCI NIH HHS CA83925NCI NIH HHS R01 CA083925NCI NIH HHS R01 CA119131PHS HHS 119131
6 · The paper itself

Abstract

Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex. In addition to Keap1-Nrf2, dithiolethiones have the potential to modify a variety of cysteine-containing proteins in the cell. Such 'off target' reactions could contribute to either side effects or cancer-preventive efficacy. Evidence is presented here that cancer chemopreventive dithiolethiones inactivate protein tyrosine phosphatases via covalent, but thiol-labile, modification of active site residues. This observation may explain a number of previously reported cellular responses to dithiolethiones.

Indexed as

Anticarcinogenic AgentsCatalytic DomainHumansMass SpectrometryProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine PhosphatasesPyrazinesReactive Oxygen SpeciesRecombinant ProteinsThionesThiophenes1,2-dithiol-3-thioneAnticarcinogenic AgentsoltiprazProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine PhosphatasesPTPN1 protein, humanPyrazinesReactive Oxygen SpeciesRecombinant ProteinsThionesThiophenes

Identifiers

PMID20655236
PMCPMC3253851
OpenAlexW2034256265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.