ReviewCurrent opinion in cell biology2010
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.
Review in Current opinion in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 114 citations in OpenAlex.
- UPR deficiency leads to poor growth, aneuploidy, and a trade-off between ER and general proteostasis in yeast.Genes & development · 2025Article
- Energetics of whole genome doubling and genomic instability.Cancer letters · 2025Review
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3.PLoS genetics · 2025Article
- The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast.PLoS genetics · 2024Article
- The Spiral Model of Evolution: Stable Life Forms of Organisms and Unstable Life Forms of Cancers.International journal of molecular sciences · 2024Review
- Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress.Annual review of microbiology · 2023Review
- The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations.Molecular biology and evolution · 2022Article
- Review
- Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling.Journal of the American Heart Association · 2021Article
- Combining targeted sequencing and ultra-low-pass whole-genome sequencing for accurate somatic copy number alteration detection.Functional & integrative genomics · 2021Article
- Expression attenuation as a mechanism of robustness against gene duplication.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Aneuploid Circulating Tumor Cells as a Predictor of Response to Neoadjuvant Chemotherapy in Non-Small Cell Lung Cancer.International journal of general medicine · 2021Article
- Patterns of Genomic Instability in Interspecific Yeast Hybrids With Diverse Ancestries.Frontiers in fungal biology · 2021Article
- P53 induces senescence in the unstable progeny of aneuploid cells.Cell cycle (Georgetown, Tex.) · 2020Article
- SUMO and cellular adaptive mechanisms.Experimental & molecular medicine · 2020Review
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we credit it to genome evolution. From a cellular perspective, however, both processes are outcomes of the same fundamental biological properties-genome and pathway plasticity and the natural selection of cells that escape death and acquire growth advantages. Unraveling the consequences of genome plasticity at a cellular level is not only central to the understanding of species evolution but also crucial to deciphering important cell biological problems, such as how cancer cells emerge and how pathogens develop drug resistance. Aside from the well-known role of DNA sequence mutations, recent evidence suggests that changes in DNA copy numbers in the form of segmental or whole-chromosome aneuploidy can bring about large phenotypic variation. Although usually detrimental under conditions suitable for normal proliferation of euploid cells, aneuploidization may be a frequently occurring genetic change that enables pathogens or cancer cells to escape physiological or pharmacological roadblocks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.