ArticleClinical rheumatology1991
Osteopenia in systemic sclerosis. Evidence of a participating role of earlier menopause.
Article in Clinical rheumatology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR).Therapeutic advances in musculoskeletal disease · 2025Article
- Prevalence and effects of Vitamin D receptor polymorphism on bone mineral density and metabolism in patients with systemic sclerosis: a preliminary study.Clinical and experimental medicine · 2024Article
- Preventative Care in Scleroderma: What Is the Best Approach to Bone Health and Cancer Screening?Rheumatic diseases clinics of North America · 2023Review
- Prevalence and clinical associations with premature ovarian insufficiency, early menopause, and low ovarian reserve in systemic sclerosis.Clinical rheumatology · 2021Article
- Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis.Scientific reports · 2021Article
- The association between keloid and osteoporosis: real-world evidence.BMC musculoskeletal disorders · 2021Article
- Complex assessment of bone mineral density, fracture risk, vitamin D status, and bone metabolism in Hungarian systemic sclerosis patients.Arthritis research & therapy · 2019Article
- Osteoporosis in Rheumatic Diseases.International journal of molecular sciences · 2019Review
- Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Menopause and Rheumatic Disease.Rheumatic diseases clinics of North America · 2017Review
- Article
- The role of IL-1β in the bone loss during rheumatic diseases.Mediators of inflammation · 2015Review
- Risk factors for body composition abnormalities in systemic sclerosis.Clinical rheumatology · 2013Article
- Bone mineral density, bone turnover markers and fractures in patients with systemic sclerosis: a case control study.PloS one · 2013Article
- Bone density in Moroccan women with systemic scleroderma and its relationships with disease-related parameters and vitamin D status.Rheumatology international · 2012Article
- A review of the use of dual-energy X-ray absorptiometry (DXA) in rheumatology.Open access rheumatology : research and reviews · 2012Review
- Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency.Rheumatology international · 2011Article
- Reduced bone mass and normal calcium metabolism in systemic sclerosis with and without calcinosis.Clinical rheumatology · 1995Article
- Uterine prolapse in a young nulligravida with scleroderma and premature ovarian failure.International urogynecology journal and pelvic floor dysfunctionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ninety systemic sclerosis (SSc) patients, all females, none of them suffering from either renal failure or intestinal malabsorption, and 90 sex and age matched controls were investigated for bone mineral content (BMC) by dual photon-absorptiometry (Am 241, I 125) (Osteoden P, NIM) evaluated at two sites of the nondominant radius. BMC as well as bone density (BD) were found to be significantly lower in the patients than in the controls. No alteration of calcium metabolism was detected in the patients, neither were we able to find any relationship between osteopenia and the extent of the involvement of the skin or of any internal organ. We observed, however, that the percentage of the patients in menopause was significantly greater than that of the controls (p less than .001). Furthermore, menopause had occurred in the patients significantly earlier than in the controls (p less than .001). Therefore, earlier menopause can play a role in the induction of osteopenia in systemic sclerosis. Further prospective studies are needed to check the hormonal status of SSc patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.