Trial reportActa biomaterialia2010
Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure.
Trial report in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced osteomalacia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates.Odontology · 2022Article
- 3D printed composite scaffolds with dual small molecule delivery for mandibular bone regeneration.Biofabrication · 2020Article
- Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish.Scientific reports · 2018Article
- Synthesis, Characterization, and Biological Evaluation of Nanostructured Hydroxyapatite with Different Dimensions.Nanomaterials (Basel, Switzerland) · 2017Article
- Intrinsic mechanical behavior of femoral cortical bone in young, osteoporotic and bisphosphonate-treated individuals in low- and high energy fracture conditions.Scientific reports · 2016Article
- Changes in the degree of mineralization with osteoporosis and its treatment.Current osteoporosis reports · 2014Review
- High fluoride and low calcium levels in drinking water is associated with low bone mass, reduced bone quality and fragility fractures in sheep.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- A holistic hip fracture approach: individualized diagnosis and treatment after surgery.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2014Article
- Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment.SpringerPlus · 2014Article
- Trajectories of Bone Remodeling Markers and Bone Mineral Density during Treatment with Strontium Ranelate in Postmenopausal Women Previously Treated with Bisphosphonates.Clinical medicine insights. Endocrinology and diabetes · 2014Article
- Strontium ranelate: in search for the mechanism of action.Journal of bone and mineral metabolism · 2013Review
- A physiologically based pharmacokinetic model for strontium exposure in rat.Pharmaceutical research · 2013Article
- Strontium substitution for calcium in lithogenesis.The Journal of urology · 2013Article
- Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.PloS one · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strontium ranelate (SR) is one therapeutic option for reducing risk of fracture in osteoporosis. The effects of SR treatment on hydroxyapatite (HA) previously altered by bisphosphonate (BP) administration remain to be established. Patients who have received long-term BP treatment and present with persistent high fracture risk are of particular interest. Paired iliac crest biopsies from 15 patients post-BP therapy were subjected to a baseline biopsy and a follow-up biopsy after treatment with 2g SR day⁻¹ after either 6 months (n=5) or 12 months (n=10). Dual energy X-ray absorptiometry scans, serum parameters and biochemical markers were obtained. Quantitative backscattered electron imaging and energy-dispersive X-ray analyses combined with micro-X-ray fluorescence determinations were performed to observe any mineralization changes. Static 2-D histomorphometry was carried out to evaluate cellular and structural indices. After 6 months of SR treatment, increases in osteoid surface and strontium content were observed, but no other indices showed significant change. After 12 months of SR treatment, there was a significant increase in bone volume and trabecular thickness, and further increases in strontium content and backscattered signal intensity. These structural changes were accompanied by increased numbers of osteoblasts and increased osteoid surface and volume. Additionally, low bone resorption, as measured by beta-cross-laps, and a low number of osteoclasts were observed. SR treatment led to increased strontium content within the BP-HA nanocomposites and to increased osteoid indices and bone volume, which is indicative of newly formed bone, while osteoclasts were still suppressed. These data points suggest that SR might be considered as a therapeutic option for patients following long-term BP treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.