ArticleNeuroscience2010
Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 108 citations in OpenAlex.
- Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence.Psychopharmacology · 2012Trial
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.Environmental epigenetics · 2026Review
- Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder.Frontiers in cellular neuroscience · 2026Review
- Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice.Psychopharmacology · 2025Article
- Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance.Addiction biology · 2025Article
- Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse.Frontiers in neuroanatomy · 2024Review
- Projections from the nucleus accumbens shell to the ventral pallidum are involved in the control of sucrose intake in adult female rats.Brain structure & function · 2020Article
- Nucleus Accumbens Functional Connectivity with the Frontoparietal Network Predicts Subsequent Change in Body Mass Index for American Children.Brain sciences · 2020Article
- Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats.ACS chemical neuroscience · 2019Article
- Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.PLoS computational biology · 2019Article
- Article
- Reassessing wanting and liking in the study of mesolimbic influence on food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Dietary sugars: their detection by the gut-brain axis and their peripheral and central effects in health and diseases.European journal of nutrition · 2015Review
- Hormonal and neural mechanisms of food reward, eating behaviour and obesity.Nature reviews. Endocrinology · 2014Review
- Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm.Neuroscience · 2014Article
- A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade.Appetite · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Overindulgence in easily available energy-dense palatable foods is thought to be an important factor in the current obesity epidemic but the underlying neural mechanisms are not well understood. Here we demonstrate that mu-opioid receptor signaling in the nucleus accumbens may be important. Protracted suppression of endogenous mu-opioid receptor signaling focused on the nucleus accumbens shell for several days by means of microinjected beta-funaltrexamine (BFNA) diminished both "liking" of sucrose, as indicated by fewer positive hedonic orofacial responses, and the incentive reinforcement value ("wanting") of a food reward, as indicated by lower completion speed and increased time being distracted in the incentive runway. BFNA-treatment also decreased responding to sucrose and corn oil in the brief access lick paradigm, a test measuring a combination of mainly taste-guided "liking" and low-effort "wanting", as well as 4 h intake of sucrose solution. These effects were not due to nonspecific permanent neuronal changes, as they were fully reversible. We conclude that endogenous mu-opioid signaling in the nucleus accumbens is necessary for the full display of palatable food-induced hyperphagia through mechanisms including hedonic, motivational, and reinforcement processes. Development of obesity could be the result of predisposing innate differences in these mechanisms or overstimulation of these mechanisms by external factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.