ArticleJournal of neuroscience methods2010
Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.Biomedical optics express · 2026Article
- Transient infrared laser exposure modulates calcium activity in cortical dendritic spines.Biophotonics discovery · 2026Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Advances in the Regulation of Neural Function by Infrared Light.International journal of molecular sciences · 2024Review
- Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection?Neural regeneration research · 2023Review
- Bidirectional modulation of evoked synaptic transmission by pulsed infrared light.Scientific reports · 2022Article
- Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats.BMC complementary medicine and therapies · 2022Article
- Response of a neuronal network computational model to infrared neural stimulation.Frontiers in computational neuroscience · 2022Article
- Nanotransducers for Wireless Neuromodulation.Matter · 2021Article
- Prolonged post-stimulation response induced by 980-nm infrared neural stimulation in the rat primary motor cortex.Lasers in medical science · 2020Article
- Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.Microsystems & nanoengineering · 2020Article
- Infrared inhibition and waveform modulation of action potentials in the crayfish motor axon.Biomedical optics express · 2019Article
- Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation.Scientific reports · 2018Article
- Action potential block in neurons by infrared light.Neurophotonics · 2016Article
- Infrared neural stimulation of human spinal nerve roots in vivo.Neurophotonics · 2015Article
- Photons and neurons.Hearing research · 2014Review
- Calcium imaging of infrared-stimulated activity in rodent brain.Cell calcium · 2014Article
- Article
- Irradiation of 850-nm laser light changes the neural activities in rat primary visual cortex.Lasers in medical science · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Transient electrical impulses are conventionally used to elicit physiological responses in excitable tissues. While electrical stimulation has many advantages, it requires an electrode-tissue interface, exhibits relatively low spatial selectivity and always produces a "stimulus artifact". Recently, it has been shown that pulsed, low-energy infrared laser light can evoke nerve, muscle and sensory responses similar to those induced by traditional electrical stimulation in a contact-free, damage-free, artifact-free and spatially selective manner. However, the effect of transient infrared laser light on neurotransmission in the CNS is still largely unknown. Here, we tested the effect of infrared laser light on GABAergic neurotransmission. We recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from cultured rat cortical neurons prior to and after infrared laser stimulation. Using transient infrared laser light, we either stimulated the neuronal soma that had axonal projections to the recorded neuron or directly stimulated the axons that projected to the recorded neuron. Optical stimulation led to enhanced amplitude, decreased decay time constant and increased frequency of sIPSCs. These alterations of sIPSC properties produced by optical stimulation were specifically mediated by GABA(A) receptors and caused by the transient laser light per se since no exogenous substances such as caged compounds were used. These data show that optical stimulation using transient infrared laser light can alter GABAergic neurotransmission and demonstrate that it may be an alternative approach to electrical stimulation in studying GABAergic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.