ArticleTissue engineering. Part A2011
Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells.
Article in Tissue engineering. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 100 citations in OpenAlex.
- Composite Microparticles of Fat Graft and GFR Matrigel Improved Volume Retention by Promoting Cell Migration and Vessel Regeneration.Aesthetic plastic surgery · 2024Article
- The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals.Cell and tissue banking · 2024Review
- Enhancement of Collagen-I Levels in Human Gingival Fibroblasts by Small Molecule Activation of HIF-1α.Journal of agricultural and food chemistry · 2023Article
- Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022Review
- Prednisolone and mesenchymal stem cell preloading protect liver cell migration and mitigate extracellular matrix modification in transplanted decellularized rat liver.Stem cell research & therapy · 2022Article
- Antibiotic-Eluting Envelopes to Prevent Cardiac-Implantable Electronic Device Infection: Past, Present, and Future.Cureus · 2021Review
- Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute.Regenerative biomaterials · 2021Article
- Vessel Wall-Derived Mesenchymal Stromal Cells Share Similar Differentiation Potential and Immunomodulatory Properties with Bone Marrow-Derived Stromal Cells.Stem cells international · 2020Article
- Article
- The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury.Tissue engineering. Part A · 2019Article
- Cold atmospheric plasma is a viable solution for treating orthopedic infection: a review.Biological chemistry · 2018Review
- Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.Advanced drug delivery reviews · 2018Review
- Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair.Frontiers in bioengineering and biotechnology · 2017Article
- Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation.Journal of tissue engineering and regenerative medicine · 2016Article
- Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1.Tissue engineering. Part A · 2016Article
- Injectable Extracellular Matrix Hydrogels as Scaffolds for Spinal Cord Injury Repair.Tissue engineering. Part A · 2016Article
- Strategies for functional bioscaffold-based skeletal muscle reconstruction.Annals of translational medicine · 2015Article
- Tissue-Specific Effects of Esophageal Extracellular Matrix.Tissue engineering. Part A · 2015Article
- Decellularization and cell seeding of whole liver biologic scaffolds composed of extracellular matrix.Journal of clinical and experimental hepatology · 2015Review
- Histologic characterization of acellular dermal matrices in a porcine model of tissue expander breast reconstruction.Tissue engineering. Part A · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue and organ injury results in alterations of the local microenvironment, including the reduction in oxygen concentration and degradation of the extracellular matrix (ECM). The response of perivascular stem cells to these microenvironment changes are of particular interest because of their wide distribution throughout the body and their potential involvement in tissue and organ response to injury. The chemotactic, mitogenic, and phenotypic responses of this stem cell population were evaluated in response to a combination of decreased oxygen concentration and the presence of ECM degradation products. Culture in low-oxygen conditions resulted in increased proliferation and migration of the cells and increased activation of the ERK signaling pathway and associated integrins without a change in cell surface marker phenotype. The addition of ECM degradation products were additive to these processes. Reactive oxygen species within the cells were increased in association with the mitogenic and chemotactic responses. The increased proliferation and chemotactic properties of this stem cell population without any changes in phenotype and differentiation potential has important implications for both in vitro cell expansion and for in vivo behavior of these cells at the site of injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.