ArticleThe Journal of comparative neurology2010
Oncomodulin identifies different hair cell types in the mammalian inner ear.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 99 citations in OpenAlex.
- CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice.iScience · 2026Article
- Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.Neuroscience bulletin · 2026Article
- Revealing heterogeneity and damage response in the adult human utricle.Nature communications · 2025Article
- Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish.Cells · 2025Article
- Expression of nestin, parvalbumin and otoferlin during cochlear development in the mouse: an immunofluorescence study.European journal of histochemistry : EJH · 2025Article
- Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China. Life sciences · 2025Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.eLife · 2024Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.bioRxiv : the preprint server for biology · 2024Article
- Mapping the developmental potential of mouse inner ear organoids at single-cell resolution.iScience · 2024Article
- Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology.Frontiers in neurology · 2024Article
- The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function.Cellular and molecular life sciences : CMLS · 2023Article
- Inflammatory Mediators of Axon Regeneration in the Central and Peripheral Nervous Systems.International journal of molecular sciences · 2023Review
- Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.The Journal of physiology · 2023Article
- A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs.Cell reports · 2023Article
- Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform.Nature communications · 2023Article
- Oral Administration of TrkB Agonist, 7, 8-Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin-Induced Vestibular Injury in Guinea Pig.Pharmaceutics · 2023Article
- TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.Nature communications · 2022Article
- Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti.NPJ Regenerative medicine · 2022Article
- Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.Cell calcium · 2022Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The tight regulation of Ca(2+) is essential for inner ear function, and yet the role of Ca(2+) binding proteins (CaBPs) remains elusive. By using immunofluorescence and reverse transcriptase-polymerase chain reaction (RT-PCR), we investigated the expression of oncomodulin (Ocm), a member of the parvalbumin family, relative to other EF-hand CaBPs in cochlear and vestibular organs in the mouse. In the mouse cochlea, Ocm is found only in outer hair cells and is localized preferentially to the basolateral outer hair cell membrane and to the base of the hair bundle. Developmentally, Ocm immunoreactivity begins as early as postnatal day (P) 2 and shows preferential localization to the basolateral membrane and hair bundle after P8. Unlike the cochlea, Ocm expression is substantially reduced in vestibular tissues at older adult ages. In vestibular organs, Ocm is found in type I striolar or central hair cells, and has a more diffuse subcellular localization throughout the hair cell body. Additionally, Ocm immunoreactivity in vestibular hair cells is present as early as E18 and is not obviously affected by mutations that cause a disruption of hair bundle polarity. We also find Ocm expression in striolar hair cells across mammalian species. These data suggest that Ocm may have distinct functional roles in cochlear and vestibular hair cells.
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