ReviewMolecular reproduction and development2010
Developmental timing of mRNA translation--integration of distinct regulatory elements.
Review in Molecular reproduction and development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF.International journal of molecular sciences · 2026Review
- Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.The Journal of biological chemistry · 2019Article
- Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation.Oncotarget · 2017Article
- Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.Scientific reports · 2017Article
- Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.Advances in experimental medicine and biology · 2017Review
- Identification of Maturation-Specific Proteins by Single-Cell Proteomics of Human Oocytes.Molecular & cellular proteomics : MCP · 2016Article
- Functional Integration of mRNA Translational Control Programs.Biomolecules · 2015Review
- Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression.European journal of medicinal chemistry · 2014Article
- Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2.The Journal of biological chemistry · 2014Article
- Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.Bioorganic & medicinal chemistry letters · 2014Article
- Article
- Proteomes of animal oocytes: what can we learn for human oocytes in the in vitro fertilization programme?BioMed research international · 2014Review
- Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.PloS one · 2014Article
- Global profiling of stimulus-induced polyadenylation in cells using a poly(A) trap.Nature chemical biology · 2013Article
- Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2.Biochimica et biophysica acta · 2013Article
- Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation.Developmental biology · 2012Article
- Multiple binding of repressed mRNAs by the P-body protein Rck/p54.RNA (New York, N.Y.) · 2012Article
- Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation.Molecular reproduction and development · 2012Article
- A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans.Developmental biology · 2012Article
- Cancer biology: The director's cut.Nature · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Targeted mRNA translation is emerging as a critical mechanism to control gene expression during developmental processes. Exciting new findings have revealed a critical role for regulatory elements within the mRNA untranslated regions to direct the timing of mRNA translation. Regulatory elements can be targeted by sequence-specific binding proteins to direct either repression or activation of mRNA translation in response to developmental signals. As new regulatory elements continue to be identified it has become clear that targeted mRNAs can contain multiple regulatory elements, directing apparently contradictory translational patterns. How is this complex regulatory input integrated? In this review, we focus on a new challenge area-how sequence-specific RNA binding proteins respond to developmental signals and functionally integrate to regulate the extent and timing of target mRNA translation. We discuss current understanding with a particular emphasis on the control of cell cycle progression that is mediated through a complex interplay of distinct mRNA regulatory elements during Xenopus oocyte maturation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.