ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023Review
- Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.Kidney international · 2022Article
- Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure.International journal of molecular sciences · 2020Article
- Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions.BMC molecular and cell biology · 2019Article
- Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis.BMB reports · 2018Article
- Identifying novel members of the Wntless interactome through genetic and candidate gene approaches.Brain research bulletin · 2018Article
- Wls Expression Correlates with Tumor Differentiation and TNM Stage in Hepatocellular Carcinoma.Digestive diseases and sciences · 2018Article
- Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.Scientific reports · 2017Article
- Strong effect of SNP rs4988300 of the LRP5 gene on bone phenotype of Caucasian postmenopausal women.Journal of bone and mineral metabolism · 2016Article
- Distinct requirements for Wntless in habenular development.Developmental biology · 2015Article
- Article
- Concentration-dependent effects of WNTLESS on WNT1/3A signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.Progress in neuro-psychopharmacology & biological psychiatry · 2014Article
- Wntless is required for peripheral lung differentiation and pulmonary vascular development.Developmental biology · 2013Article
- Article
- Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae.PloS one · 2013Article
- Review
- The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis.EMBO molecular medicine · 2012Article
- Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.Experimental neurology · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
GPR177 is an evolutionarily conserved transmembrane protein necessary for Wnt protein secretion. Little is currently known, however, regarding expression of GPR177, especially in vertebrate species. We have developed an antiserum against GPR177, and used it to examine expression of GPR177 in human tissue culture cells, adult mouse, and rat tissues, as well as developing zebrafish embryos. In rodents, GPR177 is expressed in virtually all tissue types and brain regions examined. In zebrafish, GPR177 polypeptides are expressed throughout embryogenesis, and are detectable as early as 1 hr post-fertilization. In situ hybridization analysis reveals that gpr177 mRNA expression is prominent in embryonic zebrafish brain and ear. Structural studies suggest that GPR177 is modified by N-linked sugars, and that the protein contains an even number of transmembrane segments. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.