ArticleCurrent atherosclerosis reports2010
Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials.
Article in Current atherosclerosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Rationale and design of the Early Sleeve gastrectomy In New Onset Diabetic Obese Patients (ESINODOP) trial.Endocrine · 2017Trial
- Iberian Cured-Ham Consumption Improves Endothelial Function in Healthy Subjects.The journal of nutrition, health & aging · 2017Trial
- Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study.Obesity (Silver Spring, Md.) · 2012Trial
- [Diabetes mellitus with inadequate blood sugar control increases mortality in Brazilian older adults: evidence from ELSI-Brazil].Cadernos de saude publica · 2026Article
- All-cause and cause-specific mortality in older people with and without diabetes in Norwegian home care services: a nationwide registry study.BMC geriatrics · 2025Article
- Metabolic memory: mechanisms and diseases.Signal transduction and targeted therapy · 2024Review
- Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital.Journal of Korean medical science · 2022Article
- Glycemia and Atherosclerotic Cardiovascular Disease: Exploring the Gap Between Risk Marker and Risk Factor.Frontiers in cardiovascular medicine · 2020Review
- Current Management of Type 2 Diabetes Mellitus in Primary Care Clinics in Korea.Endocrinology and metabolism (Seoul, Korea) · 2019Observational
- Intensive Glucose Control in Patients with Type 2 Diabetes - 15-Year Follow-up.The New England journal of medicine · 2019Observational
- Association of Glycemic Status During Progression of Chronic Kidney Disease With Early Dialysis Mortality in Patients With Diabetes.Diabetes care · 2017Article
- Clinical predictive factors in diabetic kidney disease progression.Journal of diabetes investigation · 2017Review
- Association of dietary intake and BMI among newly diagnosed type 2 diabetes patients attending diabetic clinics in Kampala.BMC nutrition · 2017Article
- The Contribution of Diabetes Education in the Treatment of People with Type 2 Diabetes and Risk of Cardiovascular Disease.Current atherosclerosis reports · 2016Review
- Review
- THE ROLE OF METABOLIC SURGERY FOR PATIENTS WITH OBESITY GRADE I AND TYPE 2 DIABETES NOT CONTROLLED CLINICALLY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2016Review
- How Durable Are the Effects After Metabolic Surgery?Current atherosclerosis reports · 2015Review
- Glycemic and Cholesterol Control Versus Single-Goal Control in US Veterans with Newly Diagnosed Type 2 Diabetes: A Retrospective Observational Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2015Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The United Kingdom Prospective Diabetes Study (UKPDS) and the Diabetes Chronic Complications Trial (DCCT) are two landmark trials that convincingly demonstrated that tight glycemic control has beneficial effects on microvascular end points. These studies also revealed a "legacy effect," which is a sustained benefit with respect to cardiovascular disease outcomes seen long after the conclusion of the trial. We discuss possible molecular mechanisms that could play a role in causing the legacy effect.
Indexed as
Identifiers
20652839What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.