Measurement of monocytic HLA-DR (mHLA-DR) expression in patients with severe sepsis and septic shock: assessment of immune organ failure.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis.Critical care (London, England) · 2011
   Pooled it
2. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial.Critical care (London, England) · 2013
   Trial
3. Sepsis-associated immunosuppression: mechanistic Insights, Biomarkers, and therapeutic perspectives.Molecular biology reports · 2025
   Review
4. The emerging role of ferroptosis in the pathological development and progression of sepsis.Military Medical Research · 2025
   Review
5. Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases.Intensive care medicine · 2025
   Article
6. Two Case Reports of Interferon-γ Therapy in Patients with Aspergillus Tracheobronchitis Who Developed an Immunocompromised State After Severe Abdominal Sepsis.The American journal of case reports · 2025
   Article
7. Low expression of CD39 on monocytes predicts poor survival in sepsis patients.Journal of intensive care · 2025
   Article
8. HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis.Biomedicines · 2023
   Article
9. Combination of NK and Other Immune Markers at Early Phase Stratify the Risk of Sepsis Patients: A Retrospective Study.Journal of inflammation research · 2023
   Article
10. Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis.Frontiers in immunology · 2023
    Review
11. HAUS Augmin-Like Complex Subunit 1 Influences Tumour Microenvironment and Prognostic Outcomes in Glioma.Journal of oncology · 2022
    Article
12. Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19.Journal of clinical medicine · 2021
    Review
13. COVID-19-associated acute respiratory distress syndrome (CARDS): Current knowledge on pathophysiology and ICU treatment - A narrative review.Best practice & research. Clinical anaesthesiology · 2021
    Review
14. Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions.Scientific reports · 2021
    Article
15. Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis.Annals of intensive care · 2020
    Review
16. Reduced Monocytic Human Leukocyte Antigen-DR Expression Indicates Immunosuppression in Critically Ill COVID-19 Patients.Anesthesia and analgesia · 2020
    Article
17. Use of Intravenous Immunoglobulins in Sepsis Therapy-A Clinical View.International journal of molecular sciences · 2020
    Review
18. Cytokine Removal in Critically Ill Patients Requiring Surgical Therapy for Infective Endocarditis (RECReATE): An Investigator-initiated Prospective Randomized Controlled Clinical Trial Comparing Two Established Clinical Protocols.Medicine · 2020
    Article
19. Immune biomarker-based enrichment in sepsis trials.Critical care (London, England) · 2020
    Article
20. Clinical characteristics, risk factors, immune status and prognosis of secondary infection of sepsis: a retrospective observational study.BMC anesthesiology · 2019
    Observational

Corrections and comments

• Comment on
  Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock.2010

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as