ArticleCellular and molecular life sciences : CMLS2011
An ancient cytokine, astakine, mediates circadian regulation of invertebrate hematopoiesis.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 48 citations in OpenAlex.
- An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026Article
- Crayfish hemocytes develop along the granular cell lineage.Scientific reports · 2021Article
- Identification of the neuropeptide precursor genes potentially involved in the larval settlement in the Echiuran worm Urechis unicinctus.BMC genomics · 2020Article
- Exploring the molecular basis of adaptive evolution in hydrothermal vent crab Austinograea alayseae by transcriptome analysis.PloS one · 2017Article
- From Blood to Brain: Adult-Born Neurons in the Crayfish Brain Are the Progeny of Cells Generated by the Immune System.Frontiers in neuroscience · 2017Review
- Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals.Frontiers in immunology · 2014Review
- Recent advances in crayfish hematopoietic stem cell culture: a model for studies of hemocyte differentiation and immunity.Cytotechnology · 2013Article
- Global view of the evolution and diversity of metazoan neuropeptide signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Astakine 2--the dark knight linking melatonin to circadian regulation in crustaceans.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invertebrate circulating hemocytes are key players in the innate immune defense and their continuous renewal from hematopoietic tissues is tightly regulated in crustaceans by astakine, a new family of cytokines sharing a prokineticin (PROK) domain. In vertebrates, brain PROKs function as transmitters of circadian rhythms and we present evidence that hemocyte release from hematopoietic tissues in crayfish is under circadian regulation, a direct result of rhythmic expression of astakine. We demonstrate that the observed variation in astakine expression has an impact on innate immunity assessed as susceptibility to a pathogenic Pseudomonas species. These findings enlighten the importance of comparing immune responses at fixed times not to neglect circadian regulation of innate immunity. Moreover, our results entail an evolutionary conserved function for prokineticins as mediators of circadian rhythm, and for the first time show a role for this domain in circadian regulation of hematopoiesis that may have implications also in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.