ArticleAmino acids2011
Improved identification of O-linked glycopeptides from ETD data with optimized scoring for different charge states and cleavage specificities.
Article in Amino acids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Optimization of LC-ExD methods for glycopeptides on an Omnitrap-Orbitrap platform.Analytical and bioanalytical chemistry · 2026Article
- Measuring the multifaceted roles of mucin-domain glycoproteins in cancer.Advances in cancer research · 2023Review
- Optimal Dissociation Methods Differ forJournal of proteome research · 2020Article
- Potential Plasticity of the Mannoprotein Repertoire Associated toMolecules (Basel, Switzerland) · 2020Article
- Status Report on the High-Throughput Characterization of Complex Intact O-Glycopeptide Mixtures.Journal of the American Society for Mass Spectrometry · 2018Article
- The Role of Electron Transfer Dissociation in Modern Proteomics.Analytical chemistry · 2018Review
- Chemical Glycoproteomics.Chemical reviews · 2016Review
- Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals.Molecular & cellular proteomics : MCP · 2016Article
- O-glycosylation sites identified from mucin core-1 type glycopeptides from human serum.Glycoconjugate journal · 2016Article
- Glycan side reaction may compromise ETD-based glycopeptide identification.Journal of the American Society for Mass Spectrometry · 2014Article
- Characterizing O-linked glycopeptides by electron transfer dissociation: fragmentation rules and applications in data analysis.Analytical chemistry · 2013Article
- Unusual fragmentation pathways in collagen glycopeptides.Journal of the American Society for Mass Spectrometry · 2013Article
- Article
- Targeting the glycoproteome.Glycoconjugate journal · 2013Article
- How to dig deeper? Improved enrichment methods for mucin core-1 type glycopeptides.Molecular & cellular proteomics : MCP · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This article describes the effect of re-interrogation of electron-transfer dissociation (ETD) data with newly developed analytical tools. MS/MS-based characterization of O-linked glycopeptides is discussed using data acquired from a complex mixture of O-linked glycopeptides, featuring mucin core 1-type carbohydrates with and without sialic acid, as well as after partial deglycosylation to leave only the core GalNAc units (Darula and Medzihradszky in Mol Cell Proteomics 8:2515, 2009). Information content of collision-induced dissociation spectra generated in collision cell (in QqTOF instruments) and in ion traps is compared. Interpretation of the corresponding ETD data using Protein Prospector is also presented. Search results using scoring based on the frequency of different fragment ions occurring in ETD spectra of tryptic peptides are compared with results obtained after ion weightings were adjusted to accommodate differential ion frequencies in spectra of differing charge states or cleavage specificities. We show that the improved scoring is more than doubled the glycopeptide assignments under very strict acceptance criteria. This study illustrates that "old" proteomic data may yield significant new information when re-interrogated with new, improved tools.
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Registered trials
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