ArticleEuropean journal of applied physiology2010
The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of Weekly Eccentric Overload Training on Locomotor and Mechanical Performance in Youth Soccer Players.Journal of sports science & medicine · 2025Article
- Mechanisms of eccentric contraction-induced muscle damage and nutritional supplementations for mitigating it.Journal of muscle research and cell motility · 2022Review
- Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions.The Journal of physiology · 2018Article
- l-arginine ingestion inhibits eccentric contraction-induced proteolysis and force deficit via S-nitrosylation of calpain.Physiological reports · 2018Article
- Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.Physiological reports · 2017Article
- Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment.Skeletal muscle · 2015Article
- Muscle-specific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions.Journal of muscle research and cell motility · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the effects of eccentric muscle contractions (ECC) on the content of myofibrillar proteins (my-proteins) and the catalytic activity of myofibrillar ATPase (my-ATPase) in skeletal muscles. Rat extensor digitorum longus and tibialis anterior muscles were exposed to 200-repeated ECC or isometric contractions (ISC) and used for measures of force output and for biochemical analyses, respectively. Whereas in ISC-treated muscles, full restoration of tetanic force was attained after 2 days of recovery, force developed by ECC-treated muscles remained depressed (P < 0.05) after 6 days. The total my-protein content and the relative content of myosin heavy chain (MHC) in total my-proteins were unaltered during 4 days of recovery after ECC, but fell (P < 0.05) to 55.9 and 63.4% after 6 days of recovery, respectively. my-ATPase activity expressed on a my-protein weight basis was unaltered immediately after ECC. However, it decreased (P < 0.05) to 75.3, 45.3, and 49.3% after 2, 4 and 6 days of recovery, respectively. Total maximal calpain activity measured at 5 mM Ca(2+) was significantly augmented (P < 0.05) after 2 days of recovery, reaching a level of threefold higher after 6 days. These alterations were specific for ECC and not observed for ISC. These results suggest that depressions in my-ATPase activity contribute to ECC-induced decreases in force and power which can take a number of days to recover.
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