Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2010
Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2.
Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Does Personalized Nutrition Advice Improve Dietary Intake in Healthy Adults? A Systematic Review of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Personalised digital interventions for reducing hazardous and harmful alcohol consumption in community-dwelling populations.The Cochrane database of systematic reviews · 2017Pooled it
- The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Brief alcohol interventions for adolescents and young adults: a systematic review and meta-analysis.Journal of substance abuse treatment · 2015Pooled it
- Personalized feedback interventions for college alcohol misuse: an update of Walters & Neighbors (2005).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2013Pooled it
- Clinical decision support for genetically guided personalized medicine: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- The Effects of Personalized Feedback About ALDH2*2, Alcohol Use, and Associated Health Risks on Drinking Intention and Consumption: The Role of Self-Efficacy and Perceived Threat.Alcohol, clinical & experimental research · 2026Trial
- Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial.BMC medicine · 2024Trial
- A randomized trial Examining The Impact Of Communicating Genetic And Lifestyle Risks For Obesity.Obesity (Silver Spring, Md.) · 2016Trial
- Digital Intervention Components for Preventing and Reducing Substance Use in Adolescents and Emerging Adults: A Comprehensive Scoping Review.Journal of prevention (2022) · 2026Article
- Beyond the Flush: Reframing ALDH2 Deficiency as a Public Health Risk.Public health genomics · 2026Article
- Article
- Drinking Motives and Alcohol Consumption Among Asian American Young Adults: The Moderating Role of Alcohol-Related Facial Flushing.International journal of environmental research and public health · 2025Article
- ALDH2 Deficiency and Alcohol Intake in the United States: Opportunity for Precision Cancer Prevention.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Article
- Article
- ALDH2 variance in disease and populations.Disease models & mechanisms · 2022Article
- Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study.BMC cancer · 2021Article
- Disclosing Pharmacogenetic Feedback of Caffeine via eHealth Channels, Assessment of the Methods and Effects to Behavior Change: A Pilot Study.Frontiers in digital health · 2020Article
- University Students' Willingness to Assist Fellow Students Who Experience Alcohol-Related Facial Flushing to Reduce Their Drinking.International journal of environmental research and public health · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
There is increasing interest in health interventions that incorporate genetic risk information. Although genetic feedback has been evaluated as an adjunct to smoking cessation interventions, its efficacy for reducing alcohol-related risks is unknown. The purpose of this study was to evaluate the feasibility, acceptability, and efficacy of a web-based alcohol intervention incorporating genetic feedback and risk information specific to ALDH2 genotype. The ALDH2*2 variant is associated with partial protection against alcohol dependence but confers significantly increased risk for alcohol-related cancers as a function of alcohol exposure. Two hundred Asian-American young adults were randomly assigned to receive web-based personalized genetic feedback or attention-control feedback. Genetic feedback included health risk information specific to alcohol-related cancer or alcohol dependence, depending on genotype. Outcomes included postintervention drinking behavior and theoretical correlates of behavior change. Genetic feedback and risk information resulted in significant reductions in 30-day drinking frequency and quantity among participants with the ALDH2*1/*2 genotype. Genetic feedback was rated highly by participants and also showed some effects on theoretical correlates of behavior change. Results provide initial evidence of the feasibility, acceptability, and brief efficacy of web-based genetic feedback for reducing alcohol-related health risks associated with ALDH2 genotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.