ArticleParasitology research2010
Mycoplasma hominis infection of Trichomonas vaginalis is not associated with metronidazole-resistant trichomoniasis in clinical isolates from the United States.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A systematic review of the literature on mechanisms of 5-nitroimidazole resistance inParasitology · 2020Pooled it
- Impact of pH andProceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Infinity war:Microbial cell (Graz, Austria) · 2023Review
- The Prevalence of Genital Mycoplasmas and Coinfection withMicroorganisms · 2023Article
- The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis.Parasitology research · 2022Article
- Characterisation ofInternational journal of molecular sciences · 2022Article
- Effect of the Symbiosis withAntibiotics (Basel, Switzerland) · 2022Article
- High Co-Infection Rate ofHealthcare (Basel, Switzerland) · 2021Article
- Lack of association between Mycoplasma hominis and Trichomonas vaginalis symbiosis in relation to metronidazole resistance.Parasitology research · 2020Article
- Anti-Trichomonas vaginalis activity of ursolic acid derivative: a promising alternative.Parasitology research · 2018Article
- Mycoplasma hominis impacts gene expression in Trichomonas vaginalis.Parasitology research · 2018Article
- Article
- Detecting the Diversity ofFrontiers in microbiology · 2017Article
- Challenges and Persistent Questions in the Treatment of Trichomoniasis.Current topics in medicinal chemistry · 2017Review
- Trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?Microbial cell (Graz, Austria) · 2016Review
- Trichomonas vaginalis metronidazole resistance is associated with single nucleotide polymorphisms in the nitroreductase genes ntr4Tv and ntr6Tv.Antimicrobial agents and chemotherapy · 2014Article
- Host cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis.PloS one · 2013Article
- Study on ITS1 Gene of Iranian Trichomonas vaginalis by Molecular Methods.Iranian journal of parasitology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Trichomonas vaginalis is a protozoan parasite that is the cause of the most common non-viral sexually transmitted disease, trichomoniasis. Metronidazole and tinidazole are the only drugs approved for treatment of T. vaginalis infections in the USA. However, drug resistance exists and some patients are allergic to these medications. Furthermore, the exact mechanism of metronidazole resistance remains undefined and current testing methods require several weeks before results are available. Identification of the mechanism of drug resistance may lead to the development of molecular tools to detect drug resistance, and quicker results for clinical treatment. In a recent study, Chinese T. vaginalis isolates that were polymerase chain reaction (PCR) positive for Mycoplasma hominis DNA demonstrated greater in vitro resistance to metronidazole than isolates with no evidence of M. hominis infection. To evaluate this finding in isolates from a distinct epidemiologic setting, we tested 55 T. vaginalis isolates collected from patients in the USA through the Centers for Disease Control and Prevention metronidazole susceptibility testing service. One half of the isolates demonstrated resistance to metronidazole by an in vitro sensitivity assay. Of the metronidazole-resistant T. vaginalis isolates, 18% were PCR positive for M. hominis, as were 22% of the metronidazole-susceptible T. vaginalis isolates (p = 0.746). We also observed no change in metronidazole sensitivity of two infected T. vaginalis isolates after they were cleared of their M. hominis infection by culturing the isolates in antibiotics. Thus, M. hominis infection of USA T. vaginalis isolates did not correlate with in vitro resistance to metronidazole.
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