ArticleRheumatology international2012
ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis.Medicine · 2020Pooled it
- Case-Control Study and Meta-Analysis Show a Weak Association between ANTXR2 Polymorphisms and Ankylosing Spondylitis in Chinese Han.BioMed research international · 2018Pooled it
- Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2).Annals of the rheumatic diseases · 2014Pooled it
- Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.PloS one · 2013Trial
- The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies.Annals of the rheumatic diseases · 2019Review
- A complex role of anthrax toxin receptor 2 polymorphisms and capillary morphogenesis protein 2 in ankylosing spondylitis pathogenesis.Clinical rheumatology · 2016Article
- Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province.Chinese medical journal · 2016Article
- Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis.Rheumatology international · 2016Article
- Ankylosis in ankylosing spondylitis: current concepts.Clinical rheumatology · 2015Review
- Anthrax toxin receptor 2 gene (ANTXR2) rs4333130 is associated with ankylosing spondylitis.International journal of clinical and experimental medicine · 2015Article
- rs10865331 associated with susceptibility and disease severity of ankylosing spondylitis in a Taiwanese population.PloS one · 2014Article
- A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.Nature genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strong associations between the polymorphisms of anthrax toxin receptor 2 (ANTXR2) and interleukin-1 receptor 2 (IL-1R2) and ankylosing spondylitis (AS) were identified through genome-wide scan by Australo-Anglo-American Spondyloarthritis Consortium very recently. However, the data are restricted to Caucasian patients in only the above report, and no replication study in other ethnic groups is published. Our study addresses this relationship in Chinese Han population. A cohort of 200 AS patients who satisfied the modified New York criteria and 200 ethnically matched healthy controls were recruited. All subjects were genotyped for rs4333130 of ANTXR2 and rs2310173 of IL-1R2. Genotyping was performed using the Sequenom MassARRAY system based on the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry platform. No association was observed between AS and ANTXR2 or IL-1R2 in present study, indicating that the polymorphisms in the ANTXR2 and IL-1R2 gene may not be regarded as major contributors to AS susceptibility in Chinese Han population. We also assumed that IL-1β might not be the key factor in the immunogenesis of AS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.