ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture, Japan.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit.Npj biological timing and sleep · 2026Article
- Characterizing light-dark cycles in the Neonatal Intensive Care Unit: a retrospective observational study.Frontiers in physiology · 2023Article
- Seasonality in Pediatric Cancer.Indian journal of pediatrics · 2018Article
- Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years.BMC clinical pathology · 2013Article
- Space-time clustering of childhood central nervous system tumours in Yorkshire, UK.BMC cancer · 2012Article
- Influence of photoperiod on hormones, behavior, and immune function.Frontiers in neuroendocrinology · 2011Review
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Authors and funding
5 authors.
Funding
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Abstract
objectiveEnvironmental factors present around the time of birth may induce the development of childhood cancer. Some studies suggested an excess of brain tumors in children born during the winter months. The aim of this study was to look for evidence of the seasonality of birth in children who were younger than 15 years at the time of brain tumor diagnosis in the Kumamoto Prefecture, Japan.
methodsWe surveyed 115 patients younger than 15 years who were diagnosed with primary intracranial tumors. All patients were born between 1989 and 2003.
resultsWe found a statistically significant difference between the season of their birth and the expected distribution of birth dates in the Kumamoto Prefecture (p = 0.028). Among the different diagnostic groups there was a statistically significant winter peak in the birth of patients with germ cell tumor (p = 0.001). No statistically significant seasonal patterns were detected in the birth season of patients with astrocytoma, malignant glioma, and medulloblastoma.
conclusionsAlthough our data provide modest support for a winter peak in the birth of children with brain tumors, we posit that there may be yet unknown, complex biological mechanisms that account for these putative seasonal patterns.
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