ArticleInternational journal of microbiology2010
Search for Anti-EA(D) Antibodies in Subjects with an "Isolated VCA IgG" Pattern.
Article in International journal of microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Antibodies to early EBV, CMV, and HHV6 antigens in systemic lupus erythematosus patients.Scandinavian journal of rheumatology · 2015Article
- EBV reactivation serological profile in primary Sjögren's syndrome: an underlying trigger of active articular involvement?Rheumatology international · 2013Article
- Performance of two commercially available automated immunoassays for the determination of Epstein-Barr virus serological status.Clinical and vaccine immunology : CVI · 2012Article
- Serological diagnosis of Epstein-Barr virus infection: Problems and solutions.World journal of virology · 2012Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of an "isolated viral capsid antigen (VCA) IgG" pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA) to detect anti-early antigen (EA) antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV) infections. The purpose of this work was to search for anti-EA(D) antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases) or acute (28 cases) infection on the basis of the immunoblotting results. Thirty-seven samples (28.5%) were positive for anti-EA(D), of which 25 (89.3%) had been classified by immunoblotting as indicating acute and 12 (11.8%) past EBV infection. This difference was statistically significant (P < .01). The results of our search for anti-EA(D) antibodies correctly identified nearly 90% of acute (presence) or past EBV infections (absence). When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests.
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Registered trials
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