ArticlePLoS biology2010
Multiple molecular mechanisms cause reproductive isolation between three yeast species.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 152 citations in OpenAlex.
- Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids.Nature communications · 2026Article
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- Nucleo-cytoplasmic compatibility in interspecies Saccharomyces hybrids and the destabilisation of the mitogenome by allospecific recombination.Scientific reports · 2026Article
- Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.bioRxiv : the preprint server for biology · 2026Article
- The role of mitotype variation and positive epistasis in trait differences between Saccharomyces species.Genetics · 2026Article
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.Nature ecology & evolution · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout aging.bioRxiv : the preprint server for biology · 2023Article
- Evolutionary Trajectories are Contingent on Mitonuclear Interactions.Molecular biology and evolution · 2023Article
- Mapping mitonuclear epistasis using a novel recombinant yeast population.PLoS genetics · 2023Article
- Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces.Nature communications · 2023Article
- Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom.Microbiology and molecular biology reviews : MMBR · 2022Review
- Evolution and molecular bases of reproductive isolation.Current opinion in genetics & development · 2022Review
- Temperature-Specific and Sex-Specific Fitness Effects of Sympatric Mitochondrial and Mito-Nuclear Variation inInsects · 2022Article
- Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies.Molecular biology and evolution · 2021Article
- Interspecific hybridization as a driver of fungal evolution and adaptation.Nature reviews. Microbiology · 2021Review
- Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii.G3 (Bethesda, Md.) · 2021Article
23 more citing papers are in PubMed but not listed here.
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear-mitochondrial conflict (cytonuclear incompatibility) is a specific form of Dobzhansky-Muller incompatibility previously shown to cause reproductive isolation in two yeast species. Here, we identified two new incompatible genes, MRS1 and AIM22, through a systematic study of F2 hybrid sterility caused by cytonuclear incompatibility in three closely related Saccharomyces species (S. cerevisiae, S. paradoxus, and S. bayanus). Mrs1 is a nuclear gene product required for splicing specific introns in the mitochondrial COX1, and Aim22 is a ligase encoded in the nucleus that is required for mitochondrial protein lipoylation. By comparing different species, our result suggests that the functional changes in MRS1 are a result of coevolution with changes in the COX1 introns. Further molecular analyses demonstrate that three nonsynonymous mutations are responsible for the functional differences of Mrs1 between these species. Functional complementation assays to determine when these incompatible genes altered their functions show a strong correlation between the sequence-based phylogeny and the evolution of cytonuclear incompatibility. Our results suggest that nuclear-mitochondrial incompatibility may represent a general mechanism of reproductive isolation during yeast evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.