ArticleInterdisciplinary perspectives on infectious diseases2010
Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination.
Article in Interdisciplinary perspectives on infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs.Fluids and barriers of the CNS · 2020Trial
- Cross-Omic Comparative Analysis Identifies Transcriptomic Signatures and Exploratory Gene Set-Level Signals in Sporadic Creutzfeldt-Jakob Disease.International journal of molecular sciences · 2026Article
- Evaluation of the application of Slovenia to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2024Article
- In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection.International journal of molecular sciences · 2023Article
- Evaluation of the application of the Czech Republic to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2023Article
- Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPPathogens (Basel, Switzerland) · 2023Article
- Glial functions in the blood-brain communication at the circumventricular organs.Frontiers in neuroscience · 2022Review
- Chronic wasting disease: a cervid prion infection looming to spillover.Veterinary research · 2021Review
- Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil.Viruses · 2021Review
- Scientific report on the analysis of the 2-year compulsory intensified monitoring of atypical scrapie.EFSA journal. European Food Safety Authority · 2021Article
- Article
- Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain.Scientific reports · 2020Article
- Oral and intravenous transmission of α-synuclein fibrils to mice.Acta neuropathologica · 2019Article
- Scientific opinion on chronic wasting disease (II).EFSA journal. European Food Safety Authority · 2018Article
- Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients.Emerging infectious diseases · 2017Article
- Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.Journal of virology · 2016Article
- Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus.Veterinary research · 2016Article
- Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular and tissue distribution in vivo.Scientific reports · 2016Article
- Evaluation of the application of Denmark to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2015Article
- Evaluation of the application of Finland to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion disorders are infectious, neurodegenerative diseases that affect humans and animals. Susceptibility to some prion diseases such as kuru or the new variant of Creutzfeldt-Jakob disease in humans and scrapie in sheep and goats is influenced by polymorphisms of the coding region of the prion protein gene, while other prion disorders such as fatal familial insomnia, familial Creutzfeldt-Jakob disease, or Gerstmann-Straussler-Scheinker disease in humans have an underlying inherited genetic basis. Several prion strains have been demonstrated experimentally in rodents and sheep. The progression and pathogenesis of disease is influenced by both genetic differences in the prion protein and prion strain. Some prion diseases only affect the central nervous system whereas others involve the peripheral organs prior to neuroinvasion. Many experiments undertaken in different species and using different prion strains have postulated common pathways of neuroinvasion. It is suggested that prions access the autonomic nerves innervating peripheral organs and tissues to finally reach the central nervous system. We review here published data supporting this view and additional data suggesting that neuroinvasion may concurrently or independently involve the blood vascular system.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.