ArticleOncotarget2010
c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.
Article in Oncotarget, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- MYC regulation of the miR-92-Robo1 axis in Slit-mediated commissural axon guidance.Molecular biology of the cell · 2025Article
- Review
- The role of tumor microenvironment on cancer stem cell fate in solid tumors.Cell communication and signaling : CCS · 2023Review
- Therapeutic Targeting of Exportin-1 in Childhood Cancer.Cancers · 2021Review
- Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead.Frontiers in oncology · 2021Review
- MYC in Brain Development and Cancer.International journal of molecular sciences · 2020Review
- Increased Oxidative Phosphorylation Is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells.International journal of molecular sciences · 2020Article
- Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway.Environmental science and pollution research international · 2020Article
- Cellular plasticity and the neuroendocrine phenotype in prostate cancer.Nature reviews. Urology · 2018Review
- Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish.Genome biology · 2018Article
- Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-BasedFrontiers in public health · 2018Review
- Metabolic regulation of glioma stem-like cells in the tumor micro-environment.Cancer letters · 2017Review
- Review
- Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain.Frontiers in neuroanatomy · 2017Article
- Article
- Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.Genes & development · 2016Article
- Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Article
- Cancer stem cell metabolism.Breast cancer research : BCR · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
myc genes are associated with a wide variety of human cancers including most types of nervous system tumors. While the mechanisms by which myc overexpression causes tumorigenesis are multifaceted and have yet to be clearly elucidated, they are at least in part related to endogenous myc function in normal cells. Knockout (KO) of either c-myc or N-myc genes in neural stem and precursor cells (NSC) driven by nestin-cre impairs mouse brain growth and mutation of N-myc also causes microcephaly in humans in Feingold Syndrome. To further define myc function in NSC and nervous system development, we created a double KO (DKO) for c- and N-myc using nestin-cre. The DKO mice display profoundly impaired overall brain growth associated with decreased cell cycling and migration of NSC, which are strikingly decreased in number. The DKO brain also exhibits specific changes in gene expression including downregulation of genes involved in protein and nucleotide metabolism, mitosis, and chromatin structure as well as upregulation of genes associated with differentiation. Together these data support a model of nervous system tumorigenesis in which excess myc aberrantly locks in a developmentally active chromatin state characterized by overactive cell cycling, and metabolism as well as blocked differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.